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Sodium 4-aminosalicylate is mainly used for the comprehensive treatment of tuberculosis infections. Sodium 4-aminosalicylate inhibits the growth and reproduction of Mycobacterium tuberculosis through a competitive inhibitory effect on folate synthesis. Sodium 4-aminosalicylate is effective only against mycobacteria and not against atypical mycobacteria.
Items | Specifications | Results |
Appearance | Off-white or slightly yellowish powder | Conform |
Identify | positive reaction | |
The color and clarity of the solution | It should comply with the regulations | |
m-aminophenol | ≤0.05% | Conform |
Loss on Drying | 16.0-17.5% | 16.8% |
PH | 6.5-8.5 | 7.41 |
Heavy Metals | ≤10ppm | Conform |
Ferric salt | ≤15ppm | |
Chloride | ≤0.005% | |
Sulfate | ≤0.05% | Conform |
Assay | ≥99.0% | 99.40% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 133-10-8 |
| Appearance: | A white or almost white crystalline powder |
| Purity: | 99%-101% |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Sodium 4-aminosalicylate is the sodium salt of 4-aminosalicylic acid (PAS), a synthetic antibiotic primarily used to treat tuberculosis (TB).
It is structurally related to aspirin but has antimicrobial activity.
Second-Line Anti-TB Drug: It was once a first-line medication but has been largely replaced by more effective, better-tolerated drugs like rifampicin and ethambutol. Today, it is classified as a Group D add-on drug by the WHO.
Use in Drug-Resistant TB (DR-TB): Its main modern application is as a component of combination therapy for multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) tuberculosis, where first-line options have failed.
Mechanism: It acts as an antimetabolite, competitively inhibiting folate synthesis in the Mycobacterium tuberculosis bacterium, which starves it of essential nutrients for growth.
Inflammatory Bowel Disease (IBD): Particularly for ulcerative colitis. It is considered an older alternative to mesalazine (5-aminosalicylic acid), especially in some regions where it may be more accessible.
Administration: The sodium salt form improves water solubility, allowing it to be made into tablets or powders.
Tolerability: It is notoriously poorly tolerated, with common side effects including severe gastrointestinal upset (nausea, vomiting, diarrhea), hypersensitivity reactions, and potential liver toxicity.
Resistance: It is never used alone; it must always be part of a multi-drug regimen to prevent rapid development of bacterial resistance.
In summary, Sodium 4-aminosalicylate is a niche, second-line antibiotic reserved for complex cases of drug-resistant tuberculosis and occasionally used for inflammatory bowel disease.
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