Name: China Supplier Hot Selling High Quality Glycyl-L-glutamine Monohydrate CAS 13115-71-4
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Glycyl-L-glutamine Monohydrate CAS 13115-71-4

item	specification	result
Appearance	white crystalline powder	conform
purity	99%min	99.4%

Parameters of Glycyl-L-glutamine Monohydrate CAS 13115-71-4

Product parameters
Cas number:	13115-71-4
Appearance:	white crystalline powder
Purity:	99.0%min
Package details:	25Kg/Drum
Brand:	Fortunachem

Glycyl-L-glutamine (Gly-Gln) monohydrate is a synthetic dipeptide, which means it is a molecule composed of two amino acids—glycine and L-glutamine—linked by a peptide bond. The "monohydrate" part indicates that one water molecule is associated with each dipeptide molecule in its crystalline form, which is common for stabilizing the compound.

It is not found as a direct component of proteins but is scientifically significant as a stable and highly soluble carrier for the amino acid L-glutamine.

1. Chemical Structure and Composition

Formula: Typically represented as C₇H₁₃N₃O₄ · H₂O
Components:

Glycine (Gly): The simplest amino acid, with a hydrogen atom as its side chain.
L-Glutamine (Gln): A conditionally essential amino acid with a side chain containing an amide group.
Peptide Bond: A covalent bond linking the carboxyl group of glycine to the amino group of glutamine.
Water of Crystallization (H₂O): A water molecule incorporated into the crystal lattice.

2. Primary Function and Mechanism of Action

The main purpose of Glycyl-L-glutamine is to serve as a superior delivery system for L-glutamine. Here's how it works:

The Problem with Free Glutamine: L-glutamine in its free form is highly unstable in solution. It rapidly breaks down into ammonia and pyroglutamic acid, especially when heated, sterilized, or stored in liquid form. This makes it difficult to use in intravenous (IV) nutrition or cell culture media.
The Solution with the Dipeptide: Glycyl-L-glutamine is highly stable in solution. It does not degrade like free glutamine.
In-Vivo Activation: Once administered (e.g., injected into the bloodstream), specific enzymes in the blood and tissues called dipeptidases quickly cleave the peptide bond between glycine and glutamine, releasing both amino acids for the body to use.

In essence, it's a "protected" form of glutamine that gets unpacked right where it's needed.

3. Common Uses and Applications

Clinical Nutrition (Total Parenteral Nutrition - TPN):

This is its most important application. For critically ill, surgical, or burn patients who cannot eat and rely on IV nutrition, providing glutamine is crucial. Glutamine is a key fuel for immune cells and intestinal cells.
Adding Glycyl-L-glutamine to TPN solutions allows for the safe and effective delivery of glutamine, which helps support the immune system, preserve gut barrier function, and improve patient outcomes.

Cell Culture Media:

In biotechnology and research, mammalian cells are grown in culture flasks or bioreactors. These cells require glutamine for growth.
Using Glycyl-L-glutamine in the culture media instead of free glutamine prevents the toxic buildup of ammonia, leading to healthier cells, higher yields of proteins (e.g., antibodies), and more consistent results.

Sports Nutrition & Dietary Supplements (Less Common):

While primarily a research and clinical tool, the concept of using stable dipeptides is emerging in supplements. The idea is that dipeptides like Gly-Gln might offer better absorption and stability than free glutamine powders, though this is not yet a mainstream application.

4. Key Advantages Over Free L-Glutamine

Superior Stability: Can be sterilized and stored in aqueous solutions without significant degradation.
High Solubility: Very soluble in water, making it easy to formulate.
Rapid Utilization: Efficiently hydrolyzed in the body to release its component amino acids.
Reduced Toxicity: Prevents the ammonia production associated with free glutamine decomposition.

Summary

In essence, Glycyl-L-glutamine monohydrate is not a novel therapeutic agent itself, but a highly effective and stable prodrug for L-glutamine. Its significance lies in solving the major practical problem of glutamine's instability, thereby enabling its reliable use in clinical intravenous feeding and industrial cell culture processes to support cellular health and function.