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Deoxyarbutin is a very effective tyrosinase inhibitor that has a significant blocking effect on the formation of melanin in the skin. In animal skin tests, deoxyarbutin can effectively inhibit tyrosinase activity and melanin formation in skin tissue, quickly and effectively make the skin white, and have different degrees of whitening effect on people of different skin tones, and when the ingredient is stopped, the effect can still be maintained for nearly 8 weeks, and its depigmentation effect can be completely reversed after stopping for 8 weeks, without causing permanent damage to melanocytes, and its potency is 10 times that of hydroquinone and 350 times that of ordinary arbutin.
Deoxyarbutin is a new generation of whitening actives. It is mainly used in high-grade whitening cosmetics; it can effectively inhibit tyrosinase activity, regulate the production of melanin, overcome pigmentation, and fade black spots on the skin. It has a rapid and long-lasting skin whitening effect. Deoxyarbutin also has a strong antioxidant effect.
| Item | Specifications | Results |
| Appearance | Off-white powder | Off-white powder |
| Heavy Metal | ≤10ppm | Conform |
| Loss on drying | ≤0.5% | 0.23% |
| Arsenic | ≤2ppm | Conform |
| Assay | ≥98% | 99.1% |
| Product parameters | |
| Cas number: | 53936-56-4 |
| Appearance: | Off-white powder |
| Purity: | 98% min |
| Package details: | 1kg/foil bag |
| Brand: | Fortunachem |
Deoxyarbutin is a synthetic, advanced skin-lightening agent designed to be a more stable and potent analog of arbutin, a natural compound found in bearberry plants. Both are derived from hydroquinone, a powerful but controversial depigmenting ingredient.
The core chemical structure is a hydroquinone molecule attached to a glucose unit (making it a glycoside). The critical difference from natural arbutin lies in the specific chemical bond:
Natural Arbutin has a beta-glycosidic bond.
Deoxyarbutin has an alpha-glycosidic bond and is missing one specific oxygen atom in the glucose ring (hence "de-oxy").
This seemingly small change makes deoxyarbutin more effective and stable.
Deoxyarbutin works by specifically inhibiting the enzyme tyrosinase, which is the key rate-limiting enzyme in the melanin synthesis pathway within skin melanocytes.
Targeted Delivery: The molecule is designed to be transported into melanocytes (pigment-producing skin cells).
Enzyme Inhibition: Once inside, it releases hydroquinone in a controlled manner, which directly and competitively binds to the active site of the tyrosinase enzyme.
Reduced Pigmentation: By blocking tyrosinase, it prevents the conversion of the amino acid tyrosine to melanin, thereby reducing the formation of new dark spots and evening out skin tone.
More Potent than Arbutin: Its modified structure allows for better penetration and more effective inhibition of tyrosinase compared to its natural counterpart.
More Stable than Arbutin: It is less prone to decomposition, which makes it more reliable in cosmetic formulations.
Safer Profile than Hydroquinone: Unlike pure hydroquinone, deoxyarbutin is designed to release its active component gradually and locally, potentially reducing the risk of side effects like cytotoxicity (cell death) and exogenous ochronosis (bluish-black skin discoloration) associated with long-term hydroquinone use.
In summary, deoxyarbutin is a engineered skin-lightening ingredient that offers a targeted and potent approach to inhibiting melanin production, positioning itself as a modern alternative to both natural arbutin and pure hydroquinone.
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