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Treating STIs (like chlamydia and syphilis), respiratory infections, acne, Lyme disease, and malaria prevention.
Serving as an alternative for penicillin-allergic patients.
Renal Safety: Safe for patients with kidney issues without dose adjustments.
High Bioavailability: Over 90% absorption, less affected by food.
Excellent Penetration: Effectively reaches tissues like the prostate and lungs.
Items | Specifications | Results |
Appearance | Yellow,hygroscopic,crystalline powder | Complies |
Solubility | Freely soluble in water and in methanol.sparingly soluble In ethanol(96 per cent).It dissolves in solutions of alkali hydroxides and carbonates. a) HPLC b) Sulphuric acid reaction a yellow colour develops c) It gives reaction of chlorides | Complies Complies Complies |
pH | 2.0~3.0 | 2.4 |
Specific Absorbance | At 349nm E(1%) 300~335 | 321 |
Specific optical rotation | -120°~-105° | -110° |
Heavy metals | ≤50ppm | ＜50ppm |
Light-absorbing impurities | At 490nm≤0.07 (anhydrous and ethanol-free substance) | 0.01 |
Related substances | a)6-epidoxycycline ≤2.0% b)metacycline ≤2.0% c)4-epidoxycycline ≤0.5% d)4-epi-6-epidoxycycline ≤0.5% e)oxytetracycline ≤0.5% f)2-acety-2-decarbamoyldoxycycline≤0.5% g)any unspecified impurity≤0.1% | 1.6% 0.1% 0.1% Not found Not found 0.3% Not found |
Ethanol | 4.3~6.0%(m/m) | 4.8% |
Sulphated ash | ≤0.4% | 0.08% |
Water | 1.4~2.8% | 1.9% |
Assay | 95.0%~102.0%(C22H25CIN2O8) (anhydrous and ethanol-free substance) | 96.5% |
Storage | Store in an airtight container,protected from light. | |
Conclusion | The product conforms to the above specifications. | |
Product Name:Doxycycline hyclate
CAS:24390-14-5
MF:C24H31ClN2O9
Melting point :206-209C (dec.)
form:powder
color:Yellow,hygroscopic,crystalline powder
Uses:
Doxycycline Hyclate is a semi-synthetic, broad-spectrum antibiotic belonging to the tetracycline class. It is one of the most common salt forms of doxycycline used clinically due to its high solubility and bioavailability.
Its primary mechanism involves inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing bacterial growth and replication .
Key Clinical Uses
Treatment of Specific Infections
Sexually Transmitted Infections (STIs): It is a first-line treatment for non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis and is also used for early-stage syphilis .
Respiratory and Skin Infections: Effective against atypical pneumonia (caused by Mycoplasma or Chlamydia), acute bacterial exacerbations of chronic bronchitis, and is widely used as an adjunctive therapy for moderate to severe acne vulgaris .
Vector-Borne Diseases: It is the drug of choice for Rickettsial diseases (such as Rocky Mountain Spotted Fever, Typhus, and Scrub Typhus), Lyme disease, and malaria prophylaxis .
Alternative for Penicillin-Allergic Patients
It serves as a critical alternative for treating infections like tetanus, gas gangrene, and leptospirosis in patients with a history of penicillin allergy .
Key Selling Points & Advantages
Renal Safety Profile
Unlike many other antibiotics in the tetracycline class, Doxycycline Hyclate has no significant nephrotoxicity. It is primarily eliminated via the gastrointestinal tract rather than the kidneys, making it safe for patients with renal impairment without requiring dose adjustments .
High Bioavailability and Tolerability
It is almost completely absorbed from the gastrointestinal tract (>90%), and absorption is less affected by food intake compared to other tetracyclines. This allows for flexible dosing schedules (often once or twice daily) and better patient compliance .
Excellent Tissue Penetration
Due to its high lipophilicity, it penetrates tissues and body fluids effectively, achieving high concentrations in the prostate, bile, saliva, and inflammatory exudates .
Important Safety Precautions
Contraindications: It is contraindicated in pregnant women (FDA Category D) and children under 8 years of age, as it can cause permanent tooth discoloration and inhibit skeletal development .
Administration: To prevent esophageal irritation and ulceration, it must be taken with a full glass of water, and the patient should remain upright for at least 30 minutes after ingestion .
Photosensitivity: Users may experience increased sensitivity to sunlight (phototoxicity), so sun protection is recommended during therapy .
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Azaperone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Azaperone.
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