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1-Bromo-3,5-dimethyladamantane is used as an intermediate for memantine.
Critical Pharmaceutical Intermediate: It is an essential starting material for synthesizing Memantine, a key frontline drug used to treat Alzheimer's disease.
High Purity & Quality: Commercially available with purities typically exceeding 98%, ensuring reliability for precise laboratory research and industrial pharmaceutical manufacturing.
Versatile Building Block: Its unique, bulky adamantane cage structure makes it a valuable tool in broader organic synthesis for introducing specific steric properties into complex molecules.
Commercial Availability: It is readily supplied globally in various quantities, ranging from small R&D scales to bulk industrial production.
| Items | Specifications | Results |
| Appearance | Colorless transparent oily liquid | Conforms |
| Assay | ≥99% | 99.82% |
| Product parameters | |
| Cas number: | 941-37-7 |
| Appearance: | Colorless transparent oily liquid |
| Purity: | 99%min |
| Package details: | 25kg/drum; 200kg/drum |
| Brand: | Fortunachem |
1-Bromo-3,5-dimethyladamantane (CAS: 941-37-7) is a specialized organic compound belonging to the haloalkane class. It typically appears as a colorless to pale yellow (or slightly reddish) transparent liquid that is insoluble in water but soluble in organic solvents like ether and alcohols.
Here are its primary selling points and key characteristics:
1. Critical Pharmaceutical Intermediate (Core Value)
Its most significant application is serving as a vital raw material in the synthesis of Memantine (美金刚), a prominent drug used for the treatment of Alzheimer's disease. In specific industrial processes (such as the acetonitrile method), it acts as the starting material that undergoes a Ritter reaction to build the core structure of the drug. With the growing global demand for Alzheimer's treatments, its market value is closely tied to this essential role.
2. High Purity & Quality Standards
Commercially available grades of this compound typically boast high purity levels, often ≥98.0% or ≥98.5%. Advanced preparation methods (such as using 1,3-dimethyladamantane with bromine and aluminum chloride followed by vacuum distillation) can even achieve gas chromatography purities of ≥99% with high yields, making it highly reliable for precise laboratory research and pharmaceutical manufacturing.
3. Versatile Organic Synthesis Building Block
Beyond its role in making Memantine, it is a valuable intermediate in broader organic synthesis. Its unique adamantane cage structure allows chemists to introduce specific steric and chemical properties into complex molecules, leading to various other downstream chemical products.
4. Stable Physical Properties & Availability
It has a high boiling point (around 201°C) and a stable chemical structure under normal conditions. It is readily available from numerous global chemical suppliers in various packaging sizes, ranging from small gram-level quantities for R&D to kilogram-level bulk orders for industrial production.
Note: It is classified as an irritant and combustible liquid, requiring standard safety precautions (gloves, goggles) and storage in a sealed, cool, dry, and ventilated environment.
An intermediate used for preparation of Memantine.
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