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Loratadine competitively inhibits histamine H1 receptors, inhibits allergic symptoms caused by histamine, without pronounced anticholinergic and central inhibitory effects. Loratadine is used to relieve symptoms associated with allergic rhinitis, such as sneezing, runny nose and nasal itching, as well as itching and burning sensation in the eyes. It is also used to relieve the symptoms of chronic urticaria and other allergic skin diseases.
Loratadine is a commonly used anti-allergic drug, which belongs to the second generation of long-acting tricyclic antihistamines, with the characteristics of fast onset of action, strong effect and no hormones.
Items | Specifications | Results |
Appearance | Conforms | |
Identification | IR test HPLC test | Conforms |
Assay(on the dried basis) | 98.5% ~ 101.0% | 99.5% |
Loss on drying | ≤0.5% | 0.08% |
Residue on Ignition | ≤0.1% | 0.04% |
Related substances(HPLC) | Any other individual impurity: ≤0.1% Total impurities:≤0.3% | Not detected 0.01% 0.02% |
Conclusion | The product is conforms to USP41. | |
| Product parameters | |
| Cas number: | 79794-75-5 |
| Appearance: | A White to almost white crystalline power |
| Purity: | 98.5%-101.0% |
| Package details: | 1kg/foil bag, 25kg/drum |
| Brand: | Fortunachem |
Loratadine is a common second-generation antihistamine medication used primarily to relieve allergy symptoms. It is known for its effectiveness without causing significant drowsiness, a common side effect of older (first-generation) antihistamines.
It treats symptoms associated with allergic conditions, including:
Seasonal Allergies (Hay Fever): Such as sneezing, runny or itchy nose, and watery, itchy eyes.
Year-Round Allergies: Triggered by indoor allergens like dust mites or pet dander.
Chronic Hives (Urticaria): To reduce the itching and appearance of red, raised skin welts.
Loratadine works by blocking the action of histamine, a chemical your body releases during an allergic reaction. Histamine binds to its receptors (H-1 receptors), causing inflammation and classic allergy symptoms. By occupying these receptors, loratadine prevents histamine from triggering the symptoms, providing relief.
Non-Drowsy: As a second-generation antihistamine, it is designed not to cross the blood-brain barrier easily, which minimizes sedative effects for most people.
Long-Lasting: A single dose typically provides 24-hour relief.
Over-the-Counter (OTC): It is widely available without a prescription under brand names like Claritin and various generic store brands.
Generally Well-Tolerated: It has a good safety profile, though side effects can occur (e.g., headache, dry mouth, rarely fast heartbeat).
In summary, loratadine is a popular, non-sedating antihistamine that provides day-long relief from common allergy symptoms by blocking the effects of histamine in the body.
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