Name: China Supplier High Quality Dexketoprofen Trometamol CAS 156604-79-4
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Dexketoprofen trometamol CAS 156604-79-4

Item	Specifications	Results
Appearance	White or off-white powder	Off-white powder
pH	5.5～7.0	6.3
Loss on drying	≤0.5%	≤0.05%
Sulphated ash	≤0.1%	≤0.05%
Heavy metals	≤10ppm	＜10ppm
Assay by titration(on dried basis)	98.0%～102.0%	100.5%

Parameters of Dexketoprofen trometamol CAS 156604-79-4

Product parameters
Cas number:	156604-79-4
Appearance:	White or off-white powder
Purity:	98.0%～102.0%
Package details:	1kg/bag;25kg/drum
Brand:	Fortunachem

Dexketoprofen trometamol is a fast-acting, nonsteroidal anti-inflammatory drug (NSAID) used for the short-term treatment of acute, mild to moderate pain (like musculoskeletal pain, dental pain, or menstrual cramps). It is the dextrorotatory enantiomer (the active form) of the racemic drug ketoprofen, combined with trometamol (also known as tromethamine) to enhance its solubility and speed of absorption.

1. Chemical and Pharmacological Definition

Active Ingredient: Dexketoprofen (the S(+)-enantiomer of ketoprofen).
Salt Form: Trometamol (tromethamine, an organic base).
Chemical Class: Arylpropionic acid derivative (NSAID).
Mechanism of Action: Like other NSAIDs, it works by non-selectively inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition reduces the production of prostaglandins, which are chemicals in the body that cause pain, inflammation, and fever.

The key to its effectiveness is that only the "dex" (right-handed) form is pharmacologically active. By isolating just this active form, the drug provides a more potent and rapid effect at a lower dose compared to the racemic mixture (which contains both active and inactive forms).

2. Role of Trometamol

The trometamol salt is not just an inert ingredient; it is crucial to the drug's profile:

Increased Solubility: Trometamol significantly increases the water solubility of dexketoprofen.
Faster Absorption: This enhanced solubility allows the drug to be absorbed very quickly from the gastrointestinal tract.
Rapid Onset of Action: As a result of the fast absorption, pain relief can begin in as little as 30 minutes, which is a major selling point for acute pain management.

3. Key Properties and Uses

Therapeutic Use: Management of acute pain. Common examples include:
Musculoskeletal sprains and strains
Back pain
Post-operative pain
Dental pain (e.g., after tooth extraction)
Dysmenorrhea (painful periods)
Administration: Available in several forms, including oral tablets, powder for oral solution, and for hospital use, an injectable solution.
Benefit: Its primary advantage is its rapid onset of analgesia, making it suitable for situations where quick pain relief is needed.

4. Important Safety and Side Effects

Like all NSAIDs, dexketoprofen trometamol carries risks and is intended for short-term use.

Common Side Effects: Nausea, dyspepsia (indigestion), diarrhea, dizziness.
Serious Risks:
Gastrointestinal: Ulcers, bleeding, and perforation.
Cardiovascular: Increased risk of heart attack or stroke, especially with long-term use.
Renal: Kidney toxicity.
Contraindications: It should not be used by patients with a history of ulcers, active bleeding, severe heart, liver, or kidney failure, or in the third trimester of pregnancy.
Status: Unlike valdecoxib, it is not withdrawn and remains available by prescription in many countries (e.g., across Europe, the UK, and others). It is not approved by the FDA for use in the United States.

Comparison with Other NSAIDs

Feature	Dexketoprofen Trometamol	Ibuprofen	Ketoprofen (Racemic)
Key Feature	Fast absorption, rapid pain relief	General purpose, widely available	Older, racemic mixture
Onset of Action	Very rapid (~30 min)	Moderate (1-2 hours)	Moderate (1-2 hours)
Potency	High (more potent per mg)	Moderate	Moderate
Market Status	Prescription in many countries	Over-the-counter & Prescription	Prescription (varies)

Conclusion

Dexketoprofen trometamol is an NSAID engineered for rapid and effective relief of acute pain. The combination of the active enantiomer (dexketoprofen) with the solubilizing agent (trometamol) allows it to work quickly at a lower dose. While effective, it shares the same serious gastrointestinal and cardiovascular risks as other NSAIDs and is strictly recommended for short-term use under medical supervision.