Name: China Chemical Factory Supply High Quality Verapamil hydrochloride CAS 23313-68-0 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Description	White crystalline powder	Complies
Identification	UV/NMR/HPLC	Complies
Loss on drying	Not more than 1.0%	0.10%
Assay	More than 99.0%	99.8%
Conclusion	The product conforms to the above specifications.

Verapamil Hydrochloride is a widely used pharmaceutical compound belonging to the class of non-dihydropyridine calcium channel blockers (CCBs). It is the hydrochloride salt form of Verapamil, known commercially under brand names such as Calan, Isoptin, and Verelan.

Here is a detailed breakdown of what it is and its primary selling points based on its clinical efficacy and pharmacological profile:

What is Verapamil Hydrochloride?

Mechanism of Action: It works by inhibiting the influx of calcium ions through L-type voltage-gated calcium channels in cardiac muscle and smooth muscle cells. This inhibition reduces the contractility of the heart muscle (negative inotropy), slows the heart rate (negative chronotropy), and slows electrical conduction through the atrioventricular (AV) node (negative dromotropy). It also causes vasodilation of coronary and peripheral arteries.

Chemical Identity: CAS Number 152-11-4. It is distinct from dihydropyridine CCBs (like Amlodipine or Nifedipine) because it has a more pronounced effect on the heart's electrical conduction system rather than just vascular dilation.

Forms: Available as immediate-release tablets, extended-release capsules/tablets, and injectable solutions for acute care.

Key Selling Points & Clinical Benefits

1. Superior Control of Cardiac Arrhythmias (Unique Strength)

Unlike many other blood pressure medications, Verapamil is a first-line treatment for specific heart rhythm disorders.

AV Node Modulation: Its most distinct "selling point" is its ability to slow conduction through the AV node. This makes it the drug of choice for terminating and preventing Supraventricular Tachycardia (SVT) and controlling ventricular rate in Atrial Fibrillation/Flutter.

Comparison: While dihydropyridine CCBs (e.g., Amlodipine) are poor at treating arrhythmias, Verapamil excels here, offering a dual benefit of rate control and blood pressure management in one pill.

2. Effective Angina Management

Coronary Vasodilation: It effectively dilates coronary arteries, increasing oxygen supply to the heart muscle.

Reduced Oxygen Demand: By lowering heart rate and contractility, it significantly reduces the heart's workload and oxygen consumption. This makes it highly effective for treating chronic stable angina and vasospastic (Prinzmetal's) angina.

3. Antihypertensive Efficacy with Metabolic Neutrality

Blood Pressure Control: It is a potent antihypertensive agent, effective in lowering both systolic and diastolic blood pressure.

Metabolic Profile: Unlike beta-blockers or thiazide diuretics, Verapamil generally has a neutral effect on glucose and lipid metabolism. This is a significant selling point for patients with diabetes or dyslipidemia who need blood pressure control without worsening their metabolic profile.

4. Versatile Formulations for Patient Compliance

Extended-Release (ER) Options: Modern formulations allow for once-daily dosing (e.g., 240mg ER capsules), which improves patient adherence compared to multiple daily doses required for immediate-release versions.

IV Formulation: The injectable form provides rapid onset (within minutes) for emergency conversion of SVT in hospital settings.

5. Emerging & Off-Label Research Applications

Recent research has highlighted additional potential "selling points" in specialized fields:

Cluster Headaches: It is considered the first-line preventive medication for cluster headaches, a severe and debilitating condition where few other drugs work effectively.

P-Glycoprotein (P-gp) Inhibition: In oncology research, Verapamil is known to inhibit P-gp, a protein that pumps chemotherapy drugs out of cancer cells. This suggests potential utility as an adjuvant to reverse multidrug resistance (MDR) in certain cancers, although this is primarily a research application currently.

Mania/Bipolar Disorder: Some studies suggest efficacy as a mood stabilizer in bipolar disorder, particularly for manic episodes, offering an alternative for patients who cannot tolerate lithium.

Important Safety & Differentiation Context

To fully understand its market position, one must note its specific constraints compared to competitors:

Contraindications: Due to its strong effect on heart contraction and conduction, it is contraindicated in patients with severe heart failure (reduced ejection fraction), severe hypotension, or high-grade AV block (unless a pacemaker is present). This distinguishes it from Amlodipine, which is safer in heart failure patients.

Drug Interactions: It is a moderate inhibitor of the CYP3A4 enzyme and P-gp, requiring careful management when co-administered with statins (e.g., simvastatin) or digoxin to avoid toxicity.

Summary

The primary value proposition of Verapamil Hydrochloride is its unique dual action as both a potent antihypertensive/antianginal agent and a critical antiarrhythmic drug specifically for SVT and rate control in atrial fibrillation. Its metabolic neutrality makes it ideal for diabetic patients, and its status as the gold standard for cluster headache prevention adds to its specialized utility. While it requires careful patient selection regarding heart function, its specific effects on the AV node make it irreplaceable in cardiology compared to other calcium channel blockers.