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trans-Dichlorodiamineplatinum(II) (often written as trans-[PtCl₂(NH₃)₂]) is a platinum(II) coordination complex with the following features:
Structure: Two chloride (Cl⁻) and two ammonia (NH₃) ligands arranged in a trans configuration around the central platinum ion (square planar geometry).
Isomerism: The trans isomer contrasts with the cis isomer (cisplatin), a well-known anticancer drug.
Properties: White crystalline solid, sparingly soluble in water.
Reactivity: Less biologically active than cisplatin due to its inability to form DNA crosslinks effectively.
Uses: Primarily a research compound for studying platinum coordination chemistry and DNA interaction mechanisms.
Toxicity: Less therapeutic but can still exhibit toxicity; handle with care.
Note: Unlike cisplatin, the trans isomer is not clinically used in chemotherapy due to its inefficacy in targeting cancer cells.
Items | Specifications | Results |
Appearance | Light yellow crystalline powder | Conforms |
Assay | ≥99.0% | 99.25% |
Product parameters | |
Cas number: | 14913-33-8 |
Appearance: | Light yellow crystalline powder |
Purity: | 99%min |
Package details: | 1g/vial; 10g/PE bottle |
Brand: | Fortunachem |
Used as an antineoplastic.
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