Name: China Manufacturer Supply High Quality Betamethasone 21-phosphate disodium CAS 151-73-5
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications Of Betamethasone 21-phosphate disodium CAS 151-73-5

Items	Specifications	Results
Appearance	White to practically white, odorless powder. Is hygroscopic	Practically white, odorless powder. Is hygroscopic
Solubility	Freely soluble in water and in methanol; practically insoluble in acetone and in chloroform.	Complies
Identification	A: IR B:TLC C:Identification sodium:positive	Complies Complies Positive
Specific rotation	+99°—+105°	+101.2°
Phosphate Ions	≤1.0%	Complies
Free Betamethasone	≤1.0%	0.7%
Water	≤10.0%	7.8%
Residual Solvents
Methanol	≤3000ppm	123 ppm
Acetone	≤5000ppm	185ppm
Assay	97.0-103.0%	100.1%
Conclusion	The product conforms to the above specifications.

Welcome to inqury us to get the COA of Betamethasone 21-phosphate disodium

Parameters Of Betamethasone 21-phosphate disodium CAS 151-73-5

Product parameters
Cas number:	151-73-5
Appearance:	white powder
Purity:	99.0%min
Package details:	25Kg/drum
Brand:	Fortunachem

Betamethasone 21-phosphate disodium is a synthetic, water-soluble prodrug of the potent corticosteroid betamethasone. It is a salt form created by adding a phosphate group at the 21st position, which allows it to dissolve in water for injection.

Here’s a detailed breakdown of what it is and its uses:

What it is (Pharmacology)

Prodrug: It is inactive itself. Once injected into the body, enzymes (phosphatases) rapidly remove the phosphate group, converting it into the active drug betamethasone.
Glucocorticoid: Betamethasone is a potent anti-inflammatory and immunosuppressive corticosteroid, similar to hormones produced by the adrenal glands.
Key Advantage: The phosphate ester modification makes it highly soluble in water. This allows for:

Rapid absorption into the bloodstream.
Quick onset of action (important in emergencies).
Administration via intravenous (IV) or intramuscular (IM) injection.

Primary Uses

Due to its rapid systemic availability, it is primarily used in situations requiring fast and powerful anti-inflammatory or immunosuppressive effects. It is often found in combination with other forms (like the longer-acting betamethasone acetate) in injectable suspensions, but the phosphate ester alone is used for its quick action.

Common medical uses include:

Severe Allergic Reactions and Anaphylaxis: As an adjunct to epinephrine to reduce inflammation and prevent delayed symptoms.
Shock (Septic, Hemorrhagic, etc.): Used for its anti-inflammatory effects and to support blood pressure in critical illness.
Severe Inflammatory Conditions:

Acute exacerbations of autoimmune diseases: Such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and severe dermatological conditions.
Acute respiratory conditions: Like severe asthma exacerbations or chronic obstructive pulmonary disease (COPD) flare-ups.
Cerebral edema: To reduce swelling in the brain caused by tumors or other conditions.

Endocrine Disorders: For replacement therapy in adrenal insufficiency (Addison's disease) during periods of stress or crisis.
Anti-emetic Use: To prevent nausea and vomiting, particularly in association with chemotherapy.

Important Distinctions and Formulations

Often Combined: It is frequently combined with betamethasone acetate (a longer-acting, slowly absorbed ester) in a single injection. This combination (e.g., Celestone Soluspan) provides both an immediate effect (from the phosphate) and a sustained effect lasting days to weeks (from the acetate).
Not for Local Use: Unlike betamethasone dipropionate (used in creams and ointments), the disodium phosphate salt is designed for systemic (whole-body) use via injection.
Not for Intradermal Use: It is not used in superficial injections for skin conditions like keloids or bursitis; the acetate or combined forms are used for that purpose.

Summary Table

Feature	Betamethasone 21-Phosphate Disodium
Type	Water-soluble corticosteroid prodrug
Active Form	Converts to Betamethasone in the body
Key Property	Rapid onset of action (minutes to hours)
Administration	Intravenous (IV), Intramuscular (IM) injection
Primary Role	To provide quick systemic anti-inflammatory and immunosuppressive effects
Common Uses	Severe allergies/anaphylaxis, shock, acute disease flares, cerebral edema, anti-emetic
Typical Formulation	Often combined with a longer-acting ester (acetate) in a single injectable suspension

Crucial Disclaimer: This information is for educational purposes only. Betamethasone is a potent prescription medication with significant potential side effects (e.g., hyperglycemia, immunosuppression, adrenal suppression, mood changes, osteoporosis). Its use requires careful diagnosis, dosing, and monitoring by a qualified healthcare professional.