Name: China Manufacturer Supply High Quality Best Price 2-Deoxy-D-glucose CAS 154-17-6
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of 2-Deoxy-D-glucose CAS 154-17-6

Item	Specifications	Results
Appearance	A white or almost white crystalline powder	White crystalline powder
Heavy Metal	≤10ppm	Conform
Residue on ignition	≤0.1%	0.03%
Sulfide	≤0.05%	0.01%
Loss on drying	≤0.5%	0.31%
Assay	≥98.5%	99.1%

Parameters of 2-Deoxy-D-glucose CAS 154-17-6

Product parameters
Cas number:	154-17-6
Appearance:	A white or almost white crystalline powder
Purity:	98.5% min
Package details:	100g/bag, 1kg/bag or as you require
Brand:	Fortunachem

2-Deoxy-D-glucose (2-DG) is a synthetic glucose molecule analog, meaning its chemical structure is very similar to regular glucose but with a key alteration. As the name implies, it is missing one specific oxygen atom—the hydroxyl group (-OH) attached to the second carbon atom (C-2) of the glucose ring is replaced by a hydrogen atom (-H).

This seemingly small change gives it unique biological properties, primarily functioning as a metabolic inhibitor.

How Does It Work? (Mechanism of Action)

2-DG's action is a story of mimicry and disruption:

Cellular Uptake: Cells mistake 2-DG for real glucose because it enters through the same glucose transporters on the cell membrane.
Initial Phosphorylation: Once inside the cell, the enzyme hexokinase, the first enzyme in the glycolysis pathway, phosphorylates it, converting it into 2-Deoxy-D-glucose-6-phosphate (2-DG-6-P).
Metabolic Arrest: This is the critical step. Unlike glucose-6-phosphate, 2-DG-6-phosphate cannot be further metabolized. It cannot be converted by the next enzyme in glycolysis (glucose-6-phosphate isomerase) due to the missing oxygen at the C-2 position.
Cumulative Disruption:

Glycolysis Inhibition: The accumulated 2-DG-6-P inhibits hexokinase through feedback inhibition, effectively halting the entire glycolysis pathway.
Glycogen & Glycoprotein Synthesis Disruption: It can also be mistakenly incorporated into glycogen and glycoproteins, but the missing oxygen prevents proper chain elongation, leading to dysfunctional molecules.
Energy Deprivation: By blocking glycolysis, the cell is starved of energy (ATP), especially in cells that rely heavily on this pathway.

Key Applications and Significance

Cancer Research: Cancer cells often have a high rate of glycolysis (the "Warburg effect") to fuel their rapid growth. This makes them particularly vulnerable to 2-DG, which is why it has been extensively studied as a potential anticancer and chemo-sensitizing agent.
Virology Research: Many viruses rely on the host cell's glycolytic pathway for energy to replicate. 2-DG has shown promise in inhibiting the replication of various viruses by depriving them of this crucial energy source.
Medical Imaging: In positron emission tomography (PET), a radioactive version of a similar compound, Fluorodeoxyglucose (FDG), is used. FDG acts much like 2-DG and accumulates in metabolically active cells (like cancer cells), allowing them to be visualized.
Therapeutic Use: In 2021, an oral formulation of 2-DG was granted emergency use authorization in India as an adjunct therapy for moderate to severe COVID-19 patients to help reduce oxygen dependence.

In summary, 2-Deoxy-D-glucose is a glucose analog that acts as a metabolic poison by disrupting glycolysis and other glucose-dependent processes, making it a valuable tool in research and a potential therapeutic agent for diseases like cancer and viral infections.