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Toradol has anti-inflammatory, analgesic and antipyretic activities.
Ketorolac tromethamine is a pharmaceutical salt formed by combining the acidic NSAID ketorolac with the organic base tromethamine. This chemical modification is crucial for its primary pharmaceutical application: it dramatically increases water solubility, enabling the formulation of injectable and ophthalmic solutions for short-term, potent pain relief.
In a broader chemical context, its uses include:
Analytical Standard: A precise reference material for drug quality control testing (e.g., HPLC, spectroscopy).
Biochemical Probe: A research tool to inhibit cyclooxygenase (COX) enzymes and study inflammation pathways.
Model Compound: In pharmaceutical development for designing novel salt forms or drug delivery systems to optimize solubility and stability of weakly acidic drugs.
Thus, beyond its medical role, it serves as a key example of salt formation technology and a standard in analytical and biochemical laboratories.
Items | Specifications | Results |
Appearance | White or almost white crystalline powder | Conforms |
Identification | Infrared spectrum:he infrared absorption spectrum of this product should be consistent with that of the reference substance. | Conforms |
Liquid chromatogram:The retention time of the main peak of the test solution in the chromatogram recorded under the content determination item should be consistent with the retention time of the main peak of the standard solution | Conforms | |
TLC:A yellow spot with a pink to purple border appears in the spot area of the standard solution and sample solution on the plate | Conforms | |
Residue on ignition | The residual residue shall not exceed 0.1% | 0.04% |
Organic impurities | Impurities with a relative retention time of 0.54 should not exceed 0.5% | Undetectable |
Ketorolac l-hydroxy analogues do not exceed 0.1% | undetectable | |
Ketorolac l-keto analogs should not exceed 0.1% | undetectable | |
Impurities with a relative retention time of 0.66 should not exceed 0.5% | undetectable | |
Ketorolac l-keto analogs should not exceed 0.1% | 0.0044% | |
Residual solvent | Methanol must not exceed 3000ppm | undetectable |
Ethanol must not exceed 5000ppm | 400ppm | |
Toluene should not exceed 890ppm | undetectable | |
benzene | Benzene should not exceed 2ppm | undetectable |
1.2-Dichloroethane | 1.2-Dichloroethane should not exceed 5ppm | undetectable |
Carbon tetrachloride | Must not exceed 4ppm | undetectable |
ph | 5.7~6.7 | 5.9 |
Dryness and weightlessness | No more than 0.5% | 0.09% |
Bacterial endotoxin | Must not exceed 4EU/mg | ＜4EU/mg |
Content determination | Calculated by dry product,98.5%~101.5% | 99.5% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 74103-07-4 |
| Appearance: | A white or almost white crystalline power |
| Purity: | 98.5%-101.5% |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
Ketorolac tromethamine is the tromethamine salt of ketorolac, a potent nonsteroidal anti-inflammatory drug (NSAID). Chemically, it is formed by combining the acidic ketorolac molecule with the organic base tromethamine (also known as tris(hydroxymethyl)aminomethane).
Active Moiety: Ketorolac, a carboxylic acid derivative with a structure based on a pyrrolo-pyrrole ring system.
Counterion: Tromethamine, which enhances the drug's solubility and stability.
Result: The salt formation creates a white crystalline solid that is highly soluble in water, making it suitable for injectable and ophthalmic formulations.
Its primary use is as a powerful short-term analgesic for managing moderate to severe acute pain (e.g., post-surgical, musculoskeletal), acting as a non-opioid alternative. It is available in injectable, oral, and ophthalmic forms.
Salt Formation to Optimize Drug Properties: This is the primary chemical utility. Converting ketorolac (a weak acid) into its tromethamine salt drastically increases its water solubility. This is critical for creating stable parenteral (injectable) and ophthalmic solutions with the necessary concentration and pH.
Analytical Reference Standard: In pharmaceutical analysis, ketorolac tromethamine is used as a well-defined reference standard in techniques like HPLC (High-Performance Liquid Chromatography) and UV spectroscopy to assay drug purity, potency, and stability in formulations.
Biochemical Research Tool: As a potent inhibitor of the cyclooxygenase (COX-1 and COX-2) enzymes, it is used in laboratory research to study the arachidonic acid pathway, prostaglandin biosynthesis, and mechanisms of inflammation and pain.
Formulation Studies: Its properties are studied in the development of novel drug delivery systems, such as hydrogels, nanoparticles, or topical formulations, aimed at improving delivery or reducing systemic side effects.
In summary: In a chemical context, ketorolac tromethamine is primarily significant as a pharmaceutical salt engineered for optimal solubility and stability in medicinal formulations. Its secondary uses are as a research tool in biochemistry and an analytical standard in quality control.
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