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Imatinib is used in the treatment of chronic myelogenous leukemia in early adults.
Imatinib is a novel 2-aniline pyrimidine tyrosine kinase inhibitor. It can effectively inhibit the activity of Bcr-abl tyrosine kinase, which is a product of abnormal expression of the Ph chromosome of chronic myeloid leukemia (CML), at the cellular level, so imatinib can selectively inhibit the proliferation and induce apoptosis of Ber-abl positive cell line cells and cells of patients with chronic myeloid leukemia. In addition, imatinib can also inhibit platelet-derived growth factor (PDGF) receptors, stem cell factor (SCF), and tyrosine kinases of c-Kit receptors, thereby inhibiting cell behavior mediated by PDGF and stem cell factors, but does not affect signal transduction of other stimulating factors such as epidermal growth factor.
Items | Specification | Result |
| Appearance | White or almost white powder | White powder |
| Assay(HPLC) | ≥99% | 99.83% |
| Melting point | 224-229℃ | 224-225℃ |
| Residue on ignition | ≤0.1% | 0.03% |
| Water content | ≤0.5% | 0.3% |
| Product parameters | |
| Cas number: | 152459-95-5 |
| Appearance: | White or almost white powder |
| Purity: | 99%min |
| Package details: | 1kg/foil bag |
| Brand: | Fortunachem |
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