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Griseofulvin strongly inhibits mitosis of fungal cells, interferes with fungal DNA synthesis, and binds to tubulin to prevent fungal cell division.
Griseofulvin mainly has good antibacterial effect on superficial fungi such as trichophyton, microsporidium, epidermophyte, etc., and has no antibacterial effect on candida, cryptococcus, histoplasma, sporofloc, blastomycetes, coccidioidium, etc. Griseofulvin is indicated for the treatment of various ringworm diseases, including tinea capitis, tinea baleas, tinea corporis, jock itch, tinea pedis and onychomycosis.
| Item | Specifications | Results |
| Appearance | A white or yellowish white,microfine powder | A white,microfine powder |
| Loss on drying | ≤1.0% | 0.08% |
| Acetone insolubles | 97.0% - 102.0% | 98.8% |
| Product parameters | |
| Cas number: | 126-07-8 |
| Appearance: | A white or yellowish white,microfine powder |
| Purity: | 97.0% - 102.0% |
| Package details: | 20kg/drum |
| Brand: | Fortunachem |
(+)-Griseofulvin is the biologically active, naturally occurring enantiomer of griseofulvin, an antifungal compound produced by the mold Penicillium griseofulvum. It is classified as a benzofuran spiro compound.
Its main and historical use is as a systemic antifungal drug to treat dermatophyte infections of the skin, hair, and nails (e.g., ringworm, tinea capitis, onychomycosis).
Fungistatic: It inhibits fungal growth.
Mechanism: It selectively disrupts fungal microtubule formation during mitosis, arresting cell division. It also accumulates in keratin precursor cells, making newly formed skin, hair, and nails resistant to fungal invasion.
Spectrum: Effective only against dermatophytes (Microsporum, Trichophyton, Epidermophyton).
Veterinary Medicine: Used to treat similar fungal infections in animals.
Plant Protectant: Serves as a fungicide in agriculture, particularly against certain plant pathogenic fungi like Botrytis.
While once a first-line oral treatment, its use in human medicine has declined significantly in favor of newer, broader-spectrum antifungals (like terbinafine and azoles) that have shorter treatment durations and better side-effect profiles. It remains a useful agent in specific cases and a classic example of a natural product antifungal.
In summary, (+)-Griseofulvin is a classic oral antifungal drug derived from mold, specifically used to treat ringworm and nail infections by disrupting fungal cell division, though its clinical use is now limited.
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