Name: China Supplier Hot Selling High Quality Toltrazuril CAS 69004-03-1 with Good Price
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Toltrazuril CAS 69004-03-1

Items	Specifications	Results
Character	White or almost white crystalline powder;odorless	White crystalline powder,odorless
Identification	IR spectra is consistent with CRS.	Complies
Identification	The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation,as obtained in the Assay.	Complies
Clarity & color	Colorless and clear	Complies
Fluorides	≥12.0%	12.2%
Melting point	193~196℃	194.7~195.1℃
Residue on ignition	≤0.1%	0.04%
Loss on drying	≤0.4%	0.10%
Related substances	Individual impurity ≤0.5% Total impurities ≤1.0%	0.10% 0.20%
Assay	C₁₈H₁₄F₃N₃O₄S ≥98.5%	99.6%
Conclusion	The product Complies with Toltrazuril Enterprise Standard.

Parameters of Toltrazuril CAS 69004-03-1

Product parameters
Cas number:	69004-03-1
Appearance:	White or almost white crystalline powder
Purity:	98%min
Package details:	1kg/foil bag; 25kg/drum
Brand:	Fortunachem

Toltrazuril is a broad-spectrum antiprotozoal agent primarily used in veterinary medicine. It belongs to a class of drugs known as triazinones and is specifically used to treat and prevent infections caused by coccidia (single-celled parasites) and some other related protozoa.

It is widely considered a key medication in the livestock industry and is also used in companion animals.

1. Chemical Structure and Classification

Chemical Class: It is a symmetric triazinone derivative.
Key Feature: Its unique structure allows it to be effective against multiple stages of the coccidian life cycle, which is a significant advantage over some other older anticoccidial drugs.

2. Mechanism of Action (How it Works)

Toltrazuril has a distinctive and potent mechanism of action against susceptible parasites:

Targets the Apicoplast: It specifically targets a unique organelle in these parasites called the apicoplast (a chloroplast-like structure).
Disrupts Electron Transport: It interferes with the mitochondrial and plastid electron transport systems within the parasite.
Damages All Intracellular Stages: Its effect is most pronounced on the intracellular developmental stages (schizonts and gamonts) of the parasite. It disrupts their nuclear division and cellular metabolism.
Cidal Effect: Unlike some drugs that merely inhibit growth (static effect), Toltrazuril is directly cidal, meaning it kills the parasites.

A key advantage is that it is effective throughout the parasite's life cycle, including early and late stages, which helps to break the cycle of infection and reduce environmental contamination.

3. Primary Uses in Veterinary Medicine

Toltrazuril is used in a variety of animals to control protozoal infections.

Livestock (Poultry, Swine, Calves):

Poultry: Used to prevent and treat coccidiosis caused by Eimeria species in chickens and turkeys. It is often administered via drinking water.
Swine: Used to treat and prevent coccidiosis in piglets, caused by Cystoisospora suis (formerly Isospora suis), which is a major cause of diarrhea in neonatal pigs.
Calves: Used to treat and prevent coccidiosis caused by Eimeria spp. in calves.

Companion Animals:

Pigeons & Birds: Very commonly used to treat coccidiosis in racing pigeons, aviary birds, and poultry.
Reptiles: Often used off-label to treat coccidial and related protozoal infections.
Rabbits: Used to treat Eimeria stiedae (hepatic coccidiosis) and intestinal coccidia.

Treatment of Equine Protozoal Myeloencephalitis (EPM):

While Ponazuril is the FDA-approved drug for EPM in horses, Toltrazuril is its parent compound and is also used off-label for this serious neurological disease caused by the protozoan Sarcocystis neurona.

4. Important Considerations

Safety and Selectivity: It has a wide safety margin in most species because its mechanism of action targets biological structures unique to the protozoan parasites, which are not present in the host animal's cells.
Withdrawal Period: In food-producing animals (like poultry and swine), a withdrawal period must be strictly observed. This is the time between the last dose and when the animal can be legally slaughtered for meat, ensuring no drug residues remain.
Resistance: As with all antiparasitic drugs, the potential for parasite resistance exists. Therefore, it is crucial to use it as part of a responsible rotational or strategic dosing program.

Summary

In essence, Toltrazuril is a highly effective and broad-spectrum anticoccidial drug. Its primary importance lies in its ability to kill various stages of coccidian parasites in livestock and companion animals, thereby controlling diseases that cause significant economic losses in farming and health issues in pets. Its unique triazinone structure and action on the apicoplast make it a cornerstone of veterinary protozoal infection management.