Name: China Factory Supply High Quality alpha-Lactose monohydrate CAS 5989-81-1 1 with best price
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications Of alpha-Lactose monohydrate CAS 5989-81-1

Items	Specifications	Results
Appearance	White or almost white,Crystalline powder.	Complies
Solubility	Freely but lowly soluble in water,practically insoluble in ethanol(96 per cent).	Complies
Identification A	The infrared absorption spectrum of the sample is concordant with that of the standard.	Complies
Identification B	The principal spot obtained from the Test solution corresponds in appearance and R_f value to that obtained from Standard solution A.The test is not valid unless the chromatogram obtained with Standard solution B shows four clearly discernible spots at the origin.	Complies
Residue on ignition	NMT 0.1%	0.03%
Clarity and color of solution	The solution(1g in 10ml of boiling water) isclear and nearly colorless. Determine the absorbance of this solution at a wavelength of 400 nm.The absorbance divided by the path length,in cm,is NMT 0.04	Complies 0.01
Optical rotation	+54.4°~ +55.9°,calculate on the anhydrous basis,determined at 20°	+55.2°
Acidity or alkalinity	Add 0.3ml of phenolphthalein TS:the solution is colorless,and not more than 0.4ml of 0.1N sodium hydroxide is required to produce a pink ro red color.	Complies
Loss on drying	Dry a sample at 80°for 2h. NMT 0.5%	0.06%
Water	4.5%~5.5%	4.9%
Protein and light-absorbing impurities	210-220 nm:NMT 0.25 270-300 nm:NMT 0.07	0.03 0.01
TAMC(cfu/g)	＜100	＜10
Molds and Yeasts(cfu/g)	＜50	＜10
Escherichia coli.(/10g)	absence	Not detected
Conclusion	The product conforms to the above specifications.

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Parameters Of alpha-Lactose monohydrate CAS 5989-81-1

Product parameters
Cas number:	5989-81-1
Appearance:	White powder
Purity:	98.0% - 102.0%
Package details:	25kg/bag
Brand:	Fortunachem

Alpha-D-Lactose Monohydrate - Core Definition & Key Details

Alpha-D-Lactose Monohydrate is the most common crystalline form of lactose (a disaccharide composed of glucose and galactose), containing one molecule of water of crystallization. It is a naturally occurring sugar primarily derived from bovine milk, with high purity grades manufactured for industrial and pharmaceutical applications via crystallization and purification processes.

Basic Chemical & Physical Information

CAS Number: 5989-81-1
Molecular Formula: C₁₂H₂₂O₁₁·H₂O (anhydrous lactose: C₁₂H₂₂O₁₁; monohydrate adds 1 H₂O)
Molecular Weight: 360.31 g/mol (monohydrate); 342.30 g/mol (anhydrous)
Physical Properties:

White, odorless, crystalline powder with a mild sweet taste (≈20% sweetness of sucrose).
Soluble in water (≈19 g/100 mL at 20°C), sparingly soluble in ethanol; stable under normal storage conditions (hygroscopic if exposed to high humidity).
Melting point: Decomposes at ~140°C (loses water of crystallization); anhydrous form melts at ~202°C.

Primary Uses of Alpha-D-Lactose Monohydrate

1. Pharmaceutical Industry (Largest Application)

Alpha-D-Lactose Monohydrate is a gold-standard excipient due to its excellent compressibility, flowability, and compatibility with active pharmaceutical ingredients (APIs):

Tablet Diluent/Filler: The most common use – it provides bulk to tablets (e.g., 50-90% of tablet weight for low-dose APIs like aspirin, antibiotics, or antihypertensives), enabling uniform mixing and consistent tablet size/weight. Its crystalline structure supports good compression, producing hard, stable tablets with minimal capping/lamination.
Capsule Filler: Used to fill hard gelatin capsules, especially for powdered or granular APIs, to achieve precise dosing and improve flow during capsule filling.
Dry Powder Inhaler (DPI) Carrier: Blended with micronized APIs (e.g., asthma medications like salbutamol) to enhance aerosolization and lung deposition.
Lyophilization (Freeze-Drying) Aid: Added to formulations for injectables to protect APIs from degradation during freeze-drying and improve reconstitution stability.
Binder/Disintegrant: In wet granulation processes, it acts as a mild binder (via hydration) and aids tablet disintegration in the gastrointestinal tract (dissolves slowly in water, facilitating API release).

2. Food & Beverage Industry

Dairy Products: Used to standardize lactose levels in milk, yogurt, ice cream, and cheese, improving texture, sweetness, and freeze-thaw stability.
Baked Goods: Added to bread, cakes, and pastries to enhance browning (via Maillard reaction), retain moisture, and extend shelf life; also used as a sweetener in low-sugar formulations.
Infant Formula: A key component (mimicking human milk lactose) to provide energy and support gut health in infant nutrition.
Functional Foods: Incorporated into protein bars, meal replacements, and dietary supplements as a carbohydrate source and bulking agent.

3. Cosmetics & Personal Care

Used in skincare (moisturizers, creams) and oral care (toothpaste, mouthwash) products as a humectant (retains moisture), mild sweetener, or bulking agent. It is non-irritating and compatible with most cosmetic ingredients, making it suitable for sensitive skin formulations.

4. Biotechnology & Laboratory Applications

Cell Culture Media: A carbon source for microbial and mammalian cell culture (e.g., in vaccine production, biopharmaceutical manufacturing).
Chromatography Standards: High-purity grades serve as reference materials for analytical chemistry (HPLC, GC) calibrations.

Important Notes

Grades: Multiple purity grades are available (e.g., Ph.Eur., USP/NF, Food Grade) – pharmaceutical grades require low heavy metal (<10 ppm) and microbial counts, while food grades meet FDA/EFSA safety standards.
Handling: Hygroscopic – store in a cool, dry place (20-25°C, <60% RH) to prevent clumping or conversion to anhydrous lactose.
Safety: Generally recognized as safe (GRAS) by the FDA; lactose-intolerant individuals lack lactase (the enzyme to digest lactose) and may experience gastrointestinal discomfort (bloating, diarrhea) upon ingestion.