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7-Deaza-2'-deoxyadenosine is a synthetic analog of the natural DNA nucleoside deoxyadenosine.
Key Modification: The nitrogen atom at position 7 of the adenine base is replaced with carbon (7-deaza).
Functional Impact:
Maintains standard Watson-Crick pairing with thymine.
Reduces non-canonical base pairing (e.g., Hoogsteen bonding), minimizing DNA sequencing artifacts.
Enhances nuclease resistance.
Primary Uses:
DNA Sequencing/PCR: Improves accuracy in Sanger sequencing, especially for GC-rich or structured templates.
Therapeutic Development: Serves as a precursor for antiviral/anticancer nucleoside drugs (e.g., tubercidin analogs).
Research: Probes polymerase mechanisms and nucleic acid interactions.
In short: A modified nucleoside critical for advanced molecular biology and drug design.
| Items | Specifications | Results |
| Appearance | White powder | Conforms |
| Assay | ≥97.0% | 98.35% |
| Product parameters | |
| Cas number: | 60129-59-1 |
| Appearance: | White powder |
| Purity: | 97%min |
| Package details: | 10g/bottle; 100g/foil bag |
| Brand: | Fortunachem |
7-Deaza-2'-deoxyadenosine is a chemically modified nucleoside used in biochemistry, molecular biology, and drug development. Key points:
Structure:
Derived from 2'-deoxyadenosine (a DNA building block).
The nitrogen at position 7 of the adenine base is replaced with carbon (7-deaza modification).
Key Properties:
Reduced Hoogsteen Base Pairing: Hinders non-canonical interactions, improving DNA sequencing accuracy.
Altered Hydrogen Bonding: Maintains Watson-Crick pairing with thymine but with slightly altered stability.
Resistance to Enzymatic Degradation: More stable against certain nucleases than natural deoxyadenosine.
Applications:
PCR & Sequencing: Reduces artifacts in Sanger sequencing and improves fidelity in difficult templates (e.g., GC-rich regions).
Antiviral/Anticancer Prodrugs: Serves as a precursor for therapeutics (e.g., analogues like vidarabine).
Biochemical Probes: Studies DNA polymerase mechanisms and nucleic acid interactions.
Note: Retains substrate activity for DNA polymerases, enabling enzymatic incorporation into DNA.
In short: A versatile synthetic nucleoside enhancing DNA analysis and enabling therapeutic agent design.
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