Name: China Manufacturer Supply High Quality Hydrocortisone Acetate CAS 50-03-3 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Hydrocortisone Acetate CAS 50-03-3

Items	Specifications	Results
Appearance	White or almost white crystalline powder	White crystalline powder
Specific Rotation	+158°~+167°	+164°
Loss on drying	≤1.0%	0.14%
Assay	97.0%-102.0%	99.4%

Parameters of Hydrocortisone Acetate CAS 50-03-3

Product parameters
Cas number:	50-03-3
Appearance:	White or almost white crystalline powder
Purity:	97~102%
Package details:	1kg/foil bag; 25kg/drum
Brand:	Fortunachem

Hydrocortisone Acetate: Definition and Uses

Hydrocortisone acetate is a synthetic corticosteroid medication, which is a salt ester form of the natural hormone hydrocortisone (cortisol). It is a medium-potency steroid primarily used for its anti-inflammatory, anti-itch (anti-pruritic), and immune-suppressing effects.

The "acetate" part modifies the original hydrocortisone molecule, making it less soluble and allowing it to be absorbed more slowly. This property makes it particularly useful for certain formulations where a longer-lasting, localized effect is desired.

Primary Uses and Formulations

Hydrocortisone acetate is available in several forms, each suited for different conditions:

1. Topical Preparations (Creams, Ointments, Lotions)

Used for: Treating mild to moderate inflammatory skin conditions.
Common Conditions:

Eczema (Atopic Dermatitis)
Contact Dermatitis (e.g., from poison ivy, soaps, metals)
Psoriasis (for milder cases)
Seborrheic Dermatitis (dandruff, cradle cap)
Insect Bites and Stings
Rash from Diapers (Diaper Rash) – often in combination with antifungal agents.

2. Injectable Suspension

This is a key use for the acetate form. Because it is poorly soluble, it forms a suspension that provides a slow-release, localized effect lasting for weeks when injected.

Used for: Treating inflammation and pain in a specific joint or soft tissue.
Common Conditions:

Joint Disorders: Osteoarthritis, rheumatoid arthritis, gout, bursitis.
Soft Tissue Conditions: Tendinitis, epicondylitis (tennis elbow), ganglion cysts.
Skin Lesions: Keloids, hypertrophic scars, alopecia areata (injected into the scalp).

3. Rectal Suppositories and Foams

Used for: Treating inflammation in the lower rectum and anus.
Common Conditions:

Ulcerative Colitis (distal/proctitis form)
Hemorrhoids (internal, especially when inflamed)
Proctitis (inflammation of the rectal lining)

How It Works

It mimics the action of cortisol. By binding to glucocorticoid receptors in cells, it:

Reduces inflammation by inhibiting the production of inflammatory chemicals (prostaglandins, leukotrienes).
Suppresses the immune system's overactivity in the treated area.
Constricts blood vessels, reducing redness and swelling.

Important Cautions and Side Effects

Topical Use: Should not be used on the face, groin, or armpits for prolonged periods unless directed by a doctor (risk of skin thinning, stretch marks, acne). Never use on broken or infected skin without medical advice.
Injectable Use: Injections are administered by healthcare professionals. Potential side effects include temporary pain flare, skin thinning at the injection site, lightening of the skin (depigmentation), and rarely, infection. Frequent joint injections can damage cartilage.
Systemic Absorption: While primarily local, large amounts or long-term use on large areas can lead to absorption into the bloodstream, potentially causing systemic corticosteroid side effects (e.g., adrenal suppression, high blood sugar).
Not for Infections: It does not treat bacterial, viral, or fungal infections and can actually make them worse.

Key Difference: Hydrocortisone vs. Hydrocortisone Acetate

Feature	Hydrocortisone (Base)	Hydrocortisone Acetate
Potency	Low-potency	Medium-potency
Solubility	More soluble	Less soluble (slow-release)
Common Forms	Creams, ointments (OTC), tablets, IV	Injectable suspension, suppositories, some topical creams
Typical Use	Mild skin irritation, adrenal insufficiency	Joint/soft tissue injections, rectal inflammation

Disclaimer: This information is for educational purposes only. Always consult a doctor or pharmacist before using any medication. Use exactly as prescribed, and do not use for longer than the recommended duration.