Name: China Supplier High Quality D-Dapoxetine hcl CAS 129938-20-1 / DL-Dapoxetine hcl CAS 119356-77-3
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of D-Dapoxetine hcl CAS 129938-20-1 / DL-Dapoxetine hcl CAS 119356-77-3

Items	Specifications	Results
Appearance	White or almost white crystalline powder	White crystalline powder
Loss on drying	≤1.0%	0.13%
Residue on ignition	≤0.1%	Conforms
Heavy metals	≤10ppm	Conforms
Assay	≥98.5%	99.8%

Parameters of D-Dapoxetine hcl CAS 129938-20-1 / DL-Dapoxetine hcl CAS 119356-77-3

Product parameters
Cas number:	129938-20-1/ 119356-77-3
Appearance:	White or almost white crystalline powder
Purity:	98.5%min
Package details:	1kg/foil bag; 25kg/fiber drum
Brand:	Fortunachem

Dapoxetine Hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI) specifically designed and approved for the treatment of premature ejaculation (PE) in men. It is the only oral medication approved for this condition in many countries.

It is critically important to note that it is a prescription medication and is not approved for use in women or for the treatment of depression.

How Does It Work? (Mechanism of Action)

Dapoxetine works by increasing the activity of the neurotransmitter serotonin in the brain.

Neurotransmitter Action: Serotonin is known to play a key role in delaying ejaculation. In the synaptic gap between nerve cells, serotonin helps modulate the ejaculatory reflex.
SSRI Effect: As an SSRI, Dapoxetine blocks the reabsorption (reuptake) of serotonin back into the nerve cells. This leaves more serotonin available in the synaptic gap, which helps to inhibit or delay the ejaculatory reflex.
Key Difference from Other SSRIs: Unlike SSRIs used for depression (e.g., fluoxetine, paroxetine) which are taken daily and build up over weeks, Dapoxetine is characterized by its rapid absorption and short half-life. This allows it to be taken "on-demand" (1-3 hours before anticipated sexual activity) rather than daily.

Primary Use: Premature Ejaculation (PE)

Dapoxetine is used to treat acquired or lifelong premature ejaculation in adult men. The definition of PE typically includes:

Ejaculation that always or nearly always occurs within one minute of vaginal penetration (lifelong PE).
An inability to delay ejaculation on all or nearly all vaginal penetrations.
Negative personal consequences, such as distress, bother, frustration, and/or avoidance of sexual intimacy.

Dosage and Administration

On-Demand Use: It is taken orally, typically 1 to 3 hours before sexual activity.
Not for Daily Use: It is not intended for daily dosing.
Dosage Strengths: It is available in different strengths (e.g., 30 mg and 60 mg). Treatment is usually started at the lower dose and may be increased based on efficacy and tolerability.
Frequency Limitation: It is not recommended to take it more than once every 24 hours.

Common Side Effects

Due to its potent and rapid action, side effects are common but are often mild to moderate and tend to decrease with continued use. They include:

Nausea (most common)
Headache
Dizziness
Diarrhea
Insomnia
Fatigue
Increased sweating

Important Warnings and Contraindications

Dapoxetine has several critical safety considerations due to its mechanism and effects:

Cardiovascular Risk: It is contraindicated (should not be used) in men with significant heart problems, including heart failure, conduction abnormalities (e.g., sick sinus syndrome), and significant ischemic heart disease.
Orthostatic Hypotension: It can cause a sudden drop in blood pressure upon standing, leading to dizziness, lightheadedness, and fainting. There is an increased risk if taken with alcohol.
Serotonin Syndrome: A potentially life-threatening condition can occur, especially if taken with other drugs that increase serotonin activity (e.g., other SSRIs, SNRIs, triptans for migraines, certain opioids like tramadol, and St. John's Wort).
Mania: It should not be used in people with a history of mania or bipolar disorder.
Alcohol and Other Drugs: Concurrent use with alcohol or recreational drugs is strongly discouraged as it can increase the risk of adverse events like dizziness, hypotension, and syncope (fainting).
Pregnancy and Breastfeeding: It is not indicated for use by women.

Summary

In essence, Dapoxetine Hydrochloride is a specialized, on-demand SSRI medication that effectively delays ejaculation by enhancing serotonin signaling. While it is a proven treatment for premature ejaculation, its use requires careful medical supervision due to its potential for significant side effects and serious drug interactions. A doctor must evaluate a patient's overall health and other medications before prescribing it.