Name: China Manufacturer High Purity Wholesale Price Hesperidin CAS 520-26-3
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance	Light tan to brownish-yellow powder	Complies
Taste	Characteristic	Characteristic
Odor	Characteristic	Characteristic
Identification	Must Positive	Positive
Hesperidin	≥10.0%	10.31%
Mesh Size	95% pass 80 mesh	Complies
Loss on drying	≤5.0%	3.59%
Residue on ignition	≤5.0%	3.19%
Heavy Metals	≤10.0ppm	<10.0ppm
Cd ppm	≤1.0ppm	<1.0ppm
Hg ppm	≤0.1ppm	<0.1ppm
Pb ppm	≤1.0ppm	<1.0ppm
As ppm	≤1.0ppm	<1.0ppm
Total plate count	≤1000cfu/g	Complies
Yeast &Mould	≤100cfu/g	Complies
E.Coli（CFU/g）	Negative	Negative
Salmonella/25g	Negative	Negative
Conclusion	Conform to Enterprise Standard.

Hesperidin is a naturally occurring flavonoid, specifically a type called a flavanone, which is found primarily in citrus fruits. It is most abundant in the inner peel (albedo) and membranous parts of fruits like oranges, lemons, limes, and grapefruits.

Think of it as one of the key plant compounds (phytonutrients) that gives citrus fruits their health benefits and is responsible for the integrity of their blood vessels.

Detailed Breakdown

1. Chemical Structure and Role in Plants

Class: Bioflavonoid (Citrus Bioflavonoid)
Function in Plants: In citrus fruits, hesperidin strengthens the cell walls and capillaries of the fruit. It also acts as a natural antioxidant, protecting the fruit from environmental stress like pests and disease.
Precursor: Hesperidin is the glycoside form, meaning it has a sugar molecule (rutinose) attached. When your body digests it, it removes the sugar molecule, converting it into its active, more easily absorbed form called Hesperetin.

2. Primary Natural Sources

You can find hesperidin in the edible parts of citrus fruits, but the concentrations are highest in:

Orange peel and inner white pith (albedo): This is by far the richest source.
Orange juice and fresh oranges.
Lemons and limes.
Grapefruits.
Peppermint.

Because it's concentrated in the peel, whole fruits (eaten with as much of the white pith as possible) provide more hesperidin than juice alone.

3. Key Health Benefits and Potential Uses

Hesperidin is widely studied for its potential therapeutic effects, primarily due to its powerful antioxidant and anti-inflammatory properties.

Cardiovascular Health: This is one of its most well-researched benefits.
Vascular Function: It helps improve the health of the endothelium (the inner lining of blood vessels), promoting vasodilation (widening of blood vessels) and improving blood flow.
Blood Pressure: Some studies show it can help lower high blood pressure.
Cholesterol: It may help improve lipid profiles by reducing "bad" LDL cholesterol and triglycerides.
Capillary Strength: It reduces capillary permeability and fragility, meaning it helps strengthen tiny blood vessels and can reduce bruising.
Anti-Inflammatory Effects: Hesperidin helps modulate the body's inflammatory response by inhibiting the production of pro-inflammatory compounds like cytokines. This can be beneficial for chronic inflammatory conditions.
Antioxidant Activity: It neutralizes harmful free radicals, reducing oxidative stress in the body. This activity protects cells, proteins, and DNA from damage, which is linked to chronic diseases and aging.
Brain Health: Its anti-inflammatory and antioxidant properties may have neuroprotective effects. Some research suggests it could improve blood flow to the brain and protect against neurodegenerative diseases like Alzheimer's, though more human trials are needed.
Venous Insufficiency and Hemorrhoids: Due to its ability to improve venous tone and capillary strength, hesperidin (often combined with other flavonoids like diosmin) is a common ingredient in medications and supplements used to treat symptoms of chronic venous insufficiency (e.g., leg heaviness, pain, swelling) and hemorrhoids.

4. How to Take It & Bioavailability

Dietary Intake: A diet rich in whole citrus fruits is the best way to consume hesperidin.
Supplements: Hesperidin is widely available as a dietary supplement in capsule or tablet form. It is often included in "citrus bioflavonoid" complexes.
Bioavailability Note: Pure hesperidin has relatively low bioavailability, meaning the body doesn't absorb it easily. Newer supplement formulations use Hesperidin-Methyl-Chalcone (HMC) or combine it with other compounds to enhance its absorption significantly.

5. Safety and Side Effects

Hesperidin is generally considered safe when consumed in normal dietary amounts or in recommended supplemental doses.

Side Effects: Are rare but can include mild abdominal upset or diarrhea at very high doses.
Drug Interactions: As with many supplements, there is a potential for interaction. Because it may affect blood pressure and blood clotting, individuals on blood pressure medications, blood thinners (like warfarin), or statins should consult a doctor before taking hesperidin supplements.
Pregnancy and Breastfeeding: While dietary intake from food is safe, it's best to avoid high-dose supplements during pregnancy and breastfeeding due to a lack of sufficient safety data.

Summary

Aspect	Description
What it is	A citrus bioflavonoid (phytonutrient) found in high concentrations in citrus peels and pulp.
Main Benefit	Powerful antioxidant and anti-inflammatory compound.
Key Uses	Supporting cardiovascular health, improving blood vessel function, reducing inflammation, and strengthening capillaries.
Found In	Oranges, lemons, grapefruits (especially the peel and white pith).
Considerations	Low bioavailability in its standard form; generally safe but consult a doctor if on specific medications.

In essence, hesperidin is a vital nutrient that contributes significantly to the health benefits of eating citrus fruits, particularly for the circulatory system.