Name: China Chemical Manufacturer Supply High Quality Aztreonam CAS 78110-38-0 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Aztreonam CAS 78110-38-0

Item	Specifications	Results
Appearance	White, odorless crystalline powder	Conforms
Identification	Positive	Conforms
Water	≤2.0%	0.2%
Residue on ignition	≤0.1%	0.08%
Heavy Metals	≤0.003%	Conforms
Assay	90.0 -105.0 %	95.8%

Parameters of Aztreonam CAS 78110-38-0

Product parameters
Cas number:	78110-38-0
Appearance:	White, odorless crystalline powder
Purity:	90.0 -105.0 %
Package details:	1kg/bag;25kg/drum
Brand:	Fortunachem

Aztreonam is a monocyclic beta-lactam antibiotic belonging to the monobactam class. It is a fully synthetic antibiotic designed to be resistant to beta-lactamase enzymes produced by many Gram-negative bacteria.

Chemical Characteristics

Chemical Class: Monobactam (a monocyclic beta-lactam, unlike penicillins/cephalosporins which are bicyclic).
Core Structure: Contains a β-lactam ring but lacks the fused thiazolidine or dihydrothiazine rings of penicillins/cephalosporins.
Key Functional Groups:

Sulfonic acid group (SO₃H) at the N1 position of the ring → enhances stability against β-lactamases.
Side chain mimics that of ceftazidime (aminothiazole oxime) → improves Gram-negative penetration & affinity for penicillin-binding proteins (PBPs).

Stereochemistry: The β-lactam ring and side chain are specifically configured for binding to bacterial PBPs.

Primary Medical Uses

Aztreonam is used clinically to treat Gram-negative aerobic bacterial infections, including:

Pseudomonas aeruginosa (notable for respiratory infections in cystic fibrosis patients).
E. coli, Klebsiella, Proteus, Serratia, Haemophilus influenzae.
Hospital-acquired infections (e.g., pneumonia, urinary tract infections, septicemia).
It has no activity against Gram-positive bacteria or anaerobes.

Uses in Chemistry & Research

In a chemical context, aztreonam is notable for:

Beta-Lactamase Stability Studies:

Used as a probe to study β-lactamase enzyme mechanisms due to its resistance to many (but not all) β-lactamases.
Helps classify β-lactamases (e.g., inhibited by clavulanic acid? Active against monobactams?).

Medicinal Chemistry & Drug Design:

Serves as a template for designing narrow-spectrum antibiotics (targets only Gram-negative bacteria).
Used to study structure-activity relationships (SAR) of β-lactam rings and side chains.

Chemical Synthesis:

Its synthesis involves stereoselective formation of the β-lactam ring (e.g., using cyclization of linear precursors).
Key intermediates: L-threonine-derived side chain, introduction of the sulfonate group.

Biochemical Probes:

Binds specifically to PBP3 (penicillin-binding protein 3) in Gram-negative bacteria → useful in studying cell division and peptidoglycan synthesis.

Combination Studies:

Studied in combination with other β-lactams or β-lactamase inhibitors (e.g., avibactam) to extend spectrum.

Why Chemically Distinct?

Unlike most β-lactams, aztreonam is not derived from natural products; it is purely synthetic.
Its monobactam structure avoids cross-reactivity in patients allergic to penicillins/cephalosporins (different immune recognition).

Summary Table: Chemical vs. Medical Uses

Chemical/Research Use	Medical Use
β-Lactamase mechanism studies	Treat Gram-negative bacterial infections
SAR studies for antibiotic design	Targeted therapy for Pseudomonas spp.
Probe for PBP3 binding	Hospital-acquired pneumonia/UTI
Synthetic intermediate for analogs	Cystic fibrosis respiratory infections

In summary, aztreonam is both a clinically important narrow-spectrum antibiotic and a valuable chemical tool for studying bacterial resistance, enzyme mechanisms, and antibiotic design.