Name: China Manufacturer Supply High Quality Sodium Carboxyl Methylstarch CAS 9063-38-1 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Sodium Carboxyl Methylstarch CAS 9063-38-1

item	specification	result
Appearance	white powder or almost white powder	conform
purity	2.8%-4.2%	3.05%

Parameters of Sodium Carboxyl Methylstarch CAS 9063-38-1

Product parameters
Cas number:	9063-38-1
Appearance:	white powder or almost white powder
Purity:	2.8%-4.2%
Package details:	25Kg/Drum
Brand:	Fortunachem

Sodium Carboxymethyl Starch (CMS-Na) is a chemically modified derivative of natural starch (typically from corn, potato, or tapioca). It is created by reacting starch with sodium monochloroacetate in an alkaline medium, which introduces carboxymethyl groups (-CH₂-COONa) onto the starch polymer backbone.

This modification transforms the properties of native starch, making it:

Soluble in cold water
Anionic (carries a negative charge)
Highly swellable
An excellent water-binding and viscosity-modifying agent

Note on Naming: In scientific and industrial contexts, "Sodium Carboxymethyl Starch" and "Carboxymethyl Starch Sodium" are the standard terms. "Sodium Carboxyl Methylstarch" is a common variant of the name.

Key Properties

Appearance: White or off-white, odorless, free-flowing powder or fine grains.
Solubility: Soluble in cold water, forming a clear to opalescent, viscous colloidal solution. Insoluble in organic solvents.
Swelling Power: Has a tremendous capacity to absorb water and swell many times its original volume without forming a gel (unlike some other starches).

Primary Uses and Applications

Its unique properties make it invaluable in two main industries: Pharmaceuticals and Food.

1. Pharmaceutical Uses (The Most Significant Application)

In medicine, it is widely used as a pharmaceutical excipient—an inactive substance that serves as a vehicle or medium for the active drug. Its primary role is as a:

Superdisintegrant in Tablet Formulations: This is its most critical function. When a tablet is swallowed, the superdisintegrant rapidly absorbs water, swells, and causes the tablet to break apart (disintegrate) into smaller granules. This drastically increases the surface area, allowing for the quick release and absorption of the active drug into the body. It is particularly effective in fast-melt, chewable, and orally disintegrating tablets (ODTs).
Binder and Filler: In wet granulation processes, it can help bind powder particles together. It also acts as a diluent to add bulk to a tablet.
Suspending and Viscosity-Enhancing Agent: In liquid formulations like syrups and topical lotions, it helps stabilize suspensions (preventing particles from settling) and modifies viscosity for better application.
Film-Forming Agent: Can be used in coatings for tablets or capsules.

Why is it preferred in pharmaceuticals?

Highly effective at low concentrations (typically 2-8% of tablet weight).
Chemically inert and compatible with most active ingredients.
Biocompatible, non-toxic, and derived from a natural source.
Produced to meet strict pharmacopeial standards (e.g., USP-NF, Ph. Eur.).

2. Food Industry Uses

Here, it functions as a food additive (E-number in the EU, INS 1440) and is valued for its texture-modifying properties.

Thickener and Stabilizer: Used in sauces, gravies, pie fillings, and soups to provide body and prevent separation.
Water Retention Agent: Improves moisture retention in baked goods, frozen foods, and meat products, enhancing texture and shelf-life.
Binder: In products like processed meats and vegetarian patties, it helps bind ingredients together.

3. Other Industrial Uses

Textile Industry: As a sizing agent to strengthen yarn during weaving and as a thickener in printing pastes.
Paper Industry: As a coating binder and to improve paper strength.
Detergent Industry: As a soil-suspending agent and anti-redeposition agent in powders.

Important Safety and Regulatory Information

Safety: It is generally recognized as safe (GRAS) by the FDA for use in food and is widely approved as a pharmaceutical excipient globally. It is non-toxic and biodegradable.
Allergies: While rare, as it is derived from starch (often corn), there is a theoretical concern for individuals with severe corn allergies, though the processing is extensive.
Regulatory Status: Its use in food and pharmaceuticals is strictly controlled by specifications regarding substitution degree, purity, and residual chemicals.

Comparison with Related Compounds

Compound	Source / Base	Key Property	Primary Use
Sodium Carboxymethyl Starch (CMS-Na)	Starch (corn, potato)	Cold-water soluble, super-disintegrant	Pharmaceutical tablets (disintegrant), food thickener.
Sodium Starch Glycolate	Starch (potato, corn)	Super-disintegrant (often more efficient swelling)	Pharmaceutical tablets (a major competitor to CMS-Na as a disintegrant).
Carboxymethyl Cellulose (CMC)	Cellulose (plant pulp)	Cold-water soluble, viscous, anionic	Food thickener/stabilizer, pharmaceutical binder, in cosmetics, detergents.
Native Starch	Corn, wheat, tapioca	Insoluble in cold water, must be heated to gel	Food thickener, ingredient in many foods, industrial adhesive.

Summary

Sodium Carboxymethyl Starch is a versatile, modified carbohydrate derived from starch. Its most important and specialized application is in the pharmaceutical industry as a superdisintegrant, where it is critical for ensuring that tablets dissolve rapidly in the body. Its secondary roles are as a thickener, stabilizer, and moisture-retention agent in the food and other industries. Its safety, effectiveness, and natural origin make it a staple ingredient in product formulation.

Disclaimer: This information is for educational purposes. In pharmaceuticals, excipient selection is done by formulation scientists. For food, it is used according to Good Manufacturing Practices (GMP) and regulatory limits.