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Ethyl oleate is an ester formed from oleic acid and ethanol. It's a light yellow, oily liquid used primarily as a carrier oil and penetration enhancer in intramuscular injectable medications, helping dissolve drugs and improve absorption. It's also found in cosmetics as a skin softener. Ethyl oleate is valued for its low viscosity, good solubility in oils, and safety, as the body metabolizes it into natural components. It's approved by major pharmacopeias worldwide for pharmaceutical use.
Items | Technical index |
Product name | Ethyl oleate |
CAS NO. | 111-62-6 |
Molecular formula | C20H38O2 |
Molecular weight | 310.52 |
Appearance | Light yellow to yellow liquid |
Purity | 98.5%min |
Product parameters | |
Cas number: | 111-62-6 |
Appearance: | Light yellow to yellow liquid |
Purity: | 98.5%min |
Package details: | 180kg/drum |
Brand: | Fortunachem |
Ethyl oleate is a fatty acid ester. In simple terms, it is formed when oleic acid (a common fatty acid found in many vegetable and animal fats, like olive oil) reacts with ethyl alcohol (ethanol). This reaction creates a light yellow, oily liquid.
It is best known for its role as a penetration enhancer and carrier oil in pharmaceuticals, cosmetics, and industrial applications.
Chemical Formula: C₂₀H₃₈O₂
IUPAC Name: Ethyl (Z)-octadec-9-enoate
Appearance: Clear, light yellow to amber-colored oily liquid.
Odor: Mild, characteristic, somewhat fatty or pleasant odor.
Solubility: It is insoluble in water but soluble in ethanol, ether, and most organic solvents. This property makes it excellent for blending oils and other non-polar substances.
Viscosity: It has a relatively low viscosity, meaning it's a thin, free-flowing oil.
Ethyl oleate's unique properties make it valuable in several fields:
This is its primary application. It is used as:
Carrier/Vehicle Oil: It is a common solvent for intramuscular (IM) and subcutaneous (SC) injectable drug formulations. It helps dissolve or suspend active pharmaceutical ingredients (APIs) that aren't soluble in water.
Penetration Enhancer: It improves the absorption of drugs through the skin (transdermal) or muscle tissue. It does this by temporarily disrupting the structure of the skin or tissue, allowing the drug to pass through more easily.
Cosolvent: It is used in combination with other solvents to achieve the desired solubility and stability for a drug product.
Emollient and Skin Conditioner: It acts as a lubricant on the skin's surface, giving it a soft, smooth feel. It helps reduce water loss from the skin (TEWL - Trans-Epidermal Water Loss).
Solvent: Used to dissolve other cosmetic ingredients, especially those that are oil-soluble.
Carrier for Fragrances: It helps carry and stabilize fragrance oils in products.
Lubricant: Used as a light lubricant in fine machinery and precision instruments.
Plasticizer: Added to plastics and resins to make them more flexible and workable.
Surfactant and Antifoaming Agent: Used in various industrial processes.
Solvent: For inks, dyes, and other industrial materials.
Biofuel Research: Studied as a potential component or model for biodiesel formulations.
Laboratory Chemical: Used as a solvent and reagent in chemical synthesis.
Toxicity: Ethyl oleate is generally recognized as safe for use in pharmaceuticals and cosmetics when used appropriately. It has low acute oral and dermal toxicity.
Biocompatibility: It is metabolized by the body into ethanol and oleic acid, both of which are natural substances that the body can process. This makes it a favorable choice for injectable formulations.
Regulatory Status: It is approved for use by various pharmacopeias around the world, including:
USP-NF (United States Pharmacopeia-National Formulary)
EP (European Pharmacopoeia)
BP (British Pharmacopoeia)
In essence, ethyl oleate is a versatile, non-toxic, and biodegradable ester derived from natural sources. Its primary role is as a carrier and enhancer in injectable medications, but its usefulness extends to making your skin creams smoother, your fragrances last longer, and various industrial processes run more efficiently.
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