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7-Deaza-2'-deoxyguanosine is a synthetic nucleoside analog derived from natural deoxyguanosine (a DNA building block).
Key Modification: The nitrogen atom at position 7 (N7) of the guanine base is replaced with carbon.
Functional Impact:
Maintains standard Watson-Crick pairing with cytosine (C).
Disrupts Hoogsteen bonding (critical for G-quadruplexes and non-canonical structures).
Enhances nuclease resistance and thermal stability.
Primary Uses:
DNA Sequencing: Reduces band compression in Sanger sequencing (especially GC-rich regions).
Drug Development: Precursor for antiviral/anticancer agents (e.g., nucleoside inhibitors).
Biochemical Probes: Studies DNA structures, polymerase mechanisms, and enzyme interactions.
In short: A modified guanosine essential for accurate DNA analysis and therapeutic design.
Items | Specifications | Results |
Appearance | White powder | Conforms |
Assay (HPLC) | ≥98.0% | 99.15% |
Product parameters | |
Cas number: | 86392-75-8 |
Appearance: | White powder |
Purity: | 98%min |
Package details: | 10g/bottle; 100g/foil bag |
Brand: | Fortunachem |
Synthetic DNA
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