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4-Hydrazinobenzoic acid is used as a pharmaceutical intermediate.
Items | Specifications | Results |
Appearance | Yellowish-brown to off-white powder | |
Purity(HPLC) | ≥97.0% | 99.10% |
Ele | ≤3.0% | 0.85% |
Loss on Drying | ≤1.0% | 0.30% |
Any single impurity | ≤1.0% | Complies |
Assay | 98.0%-102% | 98.72% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 619-67-0 |
| Appearance: | Light yellow powder |
| Purity: | 99.0%min |
| Package details: | 25Kg/Drum |
| Brand: | Fortunachem |
4-Hydrazinylbenzoic acid (also known as *4-Hydrazinobenzoic acid*) is an organic compound with the chemical formula C₇H₈N₂O₂. It features both a carboxylic acid (–COOH) and a hydrazine (–NHNH₂) group attached to a benzene ring at the para (1 and 4) positions.
This structure makes it a versatile bifunctional building block in organic synthesis and medicinal chemistry. It is not a drug itself but a valuable chemical intermediate.
1. Pharmaceutical Synthesis (Most Significant Use):
It is a key precursor in the synthesis of various bioactive molecules and drugs.
Antibacterial Agents: Used to create derivatives of 4-aminosalicylic acid and other compounds with antibacterial properties.
Anticancer Research: Serves as a starting material for synthesizing novel heterocyclic compounds (like benzothiazoles and triazoles) screened for antitumor activity.
Enzyme Inhibitors: The hydrazine moiety can be used to create hydrazide-based inhibitors for various enzymes.
2. Material Science & Polymer Chemistry:
Crosslinking Agent: The two reactive functional groups (–COOH and –NHNH₂) allow it to act as a crosslinker or chain extender in polymer synthesis.
Polymer Modification: Can be incorporated into polymers to introduce specific chemical reactivity or functional groups.
3. Dye and Pigment Chemistry:
Azo Dye Synthesis: The hydrazinyl group can be diazotized and used in the production of azo dyes and pigments, which are important for textiles, inks, and coatings.
4. Analytical Chemistry:
Derivatization Reagent: Can be used to modify and detect certain carbonyl compounds (like aldehydes and ketones) in analytical methods such as HPLC, forming detectable hydrazone derivatives.
Its utility stems from the dual reactivity of its functional groups:
The carboxylic acid can form esters, amides, or be reduced.
The hydrazine group is a strong nucleophile that can:
Form hydrazones with carbonyls (aldehydes/ketones).
Participate in cyclization reactions to form important nitrogen-containing heterocycles (e.g., pyrazoles, triazoles, phthalazines).
In summary, 4-Hydrazinylbenzoic acid is a specialized chemical intermediate whose primary value lies in its role as a building block for synthesizing more complex molecules—particularly in drug discovery, polymer science, and dye chemistry.
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