Name: China Supplier High Quality tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate CAS 1210348-34-7
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance	White to off-white solid	Off-white solid
Identification	The retention time of the major peak of the Sample solution corresponds to that of the Standard solution.	Complies
Water	≤1.0%	0.75%
Isomer	≤0.15%	ND
Related substances	Impurity A:≤0.3% Individual impurities:≤0.3% Total impurities:≤1.0%	ND 0.06% 0.13%
Purity	≥99.0%	99.87%
Conclusion	The product conforms to the above specifications.

This compound is a chemically synthesized organic molecule that serves as a key building block (intermediate) in medicinal chemistry and drug discovery. Its complex name describes its precise structure:

Core Structure: A cyclohexane ring with specific three-dimensional stereochemistry (1R,2S,5S). This means the relative positions of the attached groups are fixed and crucial for its biological activity.
Functional Groups:

Primary Amine (-NH₂): The reactive amine group is protected as a tert-butyl carbamate (Boc). This Boc group is a standard protecting group in organic synthesis; it masks the reactive amine during other chemical steps and can be removed later under mild acidic conditions.
Secondary Amine: Attached to the ring is a dimethylamide group [-C(O)N(CH₃)₂]. This is a common pharmacophore (part of a molecule responsible for its interaction with a biological target) that can mimic peptide bonds or participate in hydrogen bonding.

Salt Form: It is an oxalate salt. The basic amine(s) in the molecule have been reacted with oxalic acid to form a stable, crystalline, and often more easily handleable salt. This improves its purity, stability, and solubility properties for storage and use.

In summary: It is a stereochemically defined, Boc-protected diamino cyclohexane derivative, isolated as an oxalate salt.

2. Its Primary Use and Applications:

This compound is not a drug itself but a high-value synthetic intermediate. Its uses are almost exclusively in pharmaceutical research and development.

Primary Use: To synthesize more complex drug candidates, particularly those targeting proteases and kinases.

Specific Context and Examples:

Protease Inhibitor Backbone: The (1R,2S,5S)-2-amino-5-(aminocarbonyl)cyclohexyl structure is a classic scaffold found in inhibitors of various proteases (enzymes that cut proteins). It is famously known as the "Boc-DAP" backbone or related to the structure used in:

HIV Protease Inhibitors: Early classes of anti-AIDS drugs (e.g., precursors to drugs like Saquinavir) used this cyclohexylamine-derived core to mimic the natural peptide substrate of the HIV protease enzyme.
HCV Protease Inhibitors: Similar scaffolds have been explored in the development of treatments for Hepatitis C.
Other Serine/Cysteine Proteases: This scaffold is versatile and has been used in programs targeting enzymes involved in cancer, inflammation, and infectious diseases.

Kinase Inhibitor Fragment: The dimethylamide group and the basic amine make this fragment a useful component in the synthesis of kinase inhibitors (a major class of cancer drugs). The structure can act as a hinge-binding motif or a spacer element within the drug molecule.
Peptidomimetics: Its structure mimics a dipeptide (two linked amino acids) but with a rigid cyclohexane ring instead of a flexible chain. This rigidity can lead to better selectivity, potency, and metabolic stability compared to a natural peptide.

Why is it made and sold in this form?

Stereochemical Purity: The (1R,2S,5S) label confirms it's a single, specific isomer. Biological targets (enzymes, receptors) are highly sensitive to 3D shape, so this purity is essential.
Protected Amine: The Boc group allows chemists to perform reactions on other parts of the molecule without affecting the valuable -NH₂ group.
Salt Form: The oxalate salt is typically the form in which the intermediate is isolated, purified, characterized, and sold by chemical suppliers (e.g., Sigma-Aldrich, TCI, Combi-Blocks).

In a Nutshell: Think of this compound as a specialized, high-precision Lego brick used by pharmaceutical chemists to build potential new medicines, primarily for viral diseases (like HIV/HCV) and cancer. Its value lies in its defined 3D shape and reactive handles, which allow for the systematic construction of complex molecules designed to interact with specific disease targets.