English 
Español 
français 
العربية Search
Search
L-Homocysteine Thiolactone Hydrochloride is a reactive, cyclic form of the amino acid homocysteine. The "thiolactone" ring makes it highly reactive, and the "hydrochloride" salt makes it stable for lab use. Its primary significance is in biomedical research, where it is used to study the toxic effects of high homocysteine levels. It can react with proteins in a process called homocysteinylation, which is implicated in cardiovascular and neurological diseases. It's also used as a building block in organic synthesis to incorporate homocysteine into molecules.
L-Homocysteine Thiolactone Hydrochloride is a chemically reactive form of the amino acid homocysteine. It is not found in proteins but is primarily used in biochemical research and organic synthesis to study homocysteine-related biology and to incorporate homocysteine into peptides or other molecules.
L-Homocysteine: Homocysteine is a sulfur-containing amino acid produced in the body during methionine metabolism. The "L-" prefix refers to its specific three-dimensional structure (its stereoisomer), which is the form found in nature and used by the body.
Thiolactone: This describes a unique ring-shaped structure where a thiol (-SH) group reacts with a carboxyl (-COOH) group on the same molecule to form a cyclic ester (lactone). This ring is highly reactive.
Hydrochloride (HCl): This indicates the compound is a salt, making it more stable and soluble in water for laboratory use.
This compound is significant because it is a reactive metabolite implicated in cellular toxicity.
Formation In Vivo: Under certain conditions, homocysteine in the body can be mistakenly used by protein-synthesis machinery and converted into the reactive thiolactone form.
Mechanism of Toxicity: The reactive thiolactone ring can readily react with free amino groups (especially lysine residues) on proteins. This process, called protein homocysteinylation, can:
Alter the protein's structure and function.
Trigger an immune response against the modified proteins.
Contribute to endothelial dysfunction and the development of cardiovascular diseases, Alzheimer's disease, and other conditions associated with high homocysteine levels (hyperhomocysteinemia).
Biomedical Research: It is a crucial tool for scientists studying the pathological effects of elevated homocysteine. Researchers use it to induce hyperhomocysteinemia in cell cultures or animal models to investigate its role in atherosclerosis, neurodegeneration, and other diseases.
Chemical Synthesis: Its reactivity makes it a useful building block (synthon) for synthesizing more complex molecules, particularly for incorporating homocysteine into peptides or creating homocysteine derivatives.
| Feature | Description |
|---|---|
| Identity | A reactive, cyclic thioester derivative of the amino acid homocysteine, supplied as a stable hydrochloride salt. |
| Biological Role | A toxic metabolite that can modify proteins, contributing to the pathology of high homocysteine levels. |
| Primary Use | A research chemical to study homocysteine-related diseases and a reagent in organic synthesis. |
Fortunachem Provides Not Only Professional Chemical Products But Also Professional Help
Keeping you up-to-date with all the latest information, news, and events about Fortunachem!
Quick Links
Add:
E-mail:
