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Here's a concise summary of Lamotrigine :
Lamotrigine is a prescription medication primarily used to:
1️⃣ Treat epilepsy (partial seizures, tonic-clonic seizures).
2️⃣ Manage bipolar disorder (prevents depressive episodes).
Key Facts:
Mechanism: Blocks sodium channels in the brain, stabilizing nerve signals.
Dosing: Must start low and increase slowly (e.g., 25mg/day) to avoid severe skin reactions.
Serious Risk: Potential for life-threatening Stevens-Johnson syndrome (SJS)—stop immediately if rash appears.
Common Side Effects: Dizziness, headache, nausea, blurred vision.
Interactions: Levels increase with valproate, decrease with carbamazepine/oral contraceptives.
Forms: Tablets, chewables, dissolvable tablets.
Brand: Lamictal (and generics).
Always use under medical supervision due to critical titration needs and SJS risk.
Lamotrigine is a prescription medication primarily used to treat epilepsy and bipolar disorder. Here's a concise overview:
Epilepsy: Prevents partial seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome.
Bipolar Disorder: Maintains stable mood (especially for bipolar I), reducing depression relapse.
Off-label: Sometimes used for depression, neuropathic pain, or migraines.
Blocks voltage-gated sodium channels, reducing abnormal electrical brain activity.
Modulates glutamate release, calming overactive neurons.
Dosing: Must start low and increase slowly (e.g., 25mg/day initial) to avoid severe rash.
Serious Risk: Stevens-Johnson Syndrome (SJS) – a life-threatening skin reaction. Immediately stop if rash appears.
Common Side Effects: Dizziness, headache, nausea, blurred vision, insomnia.
Pregnancy: Category C – use only if benefits outweigh risks (may cause cleft palate).
Valproate ↑ lamotrigine levels (dose adjustment needed).
Carbamazepine/Phenytoin ↓ lamotrigine effectiveness.
Birth control pills may ↓ lamotrigine concentration.
Forms: Tablets, chewables, orally disintegrating tablets.
Brands: Lamictal (common), generics available.
Monitoring: Regular blood tests rarely needed; focus on symptom/response tracking.
Important: Always use under medical supervision due to titration requirements and SJS risk. Never self-adjust doses.
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