Name: China Supplier High Quality Best Price Propafenone Hydrochloride CAS 34183-22-7
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Propafenone Hydrochloride CAS 34183-22-7

Items	Specifications	Results
Appearance	White powder	Conforms
pH	5.0~6.2	5.48
Loss on drying	≤0.5%	0.05%
Residue on ignition	≤0.1%	0.06%
Single impurity	≤0.5%	0.40%
Total impurities	≤1.0%	0.55%
Assay	98%~102%	99.8%

Parameters of Propafenone Hydrochloride CAS 34183-22-7

Product parameters
Cas number:	34183-22-7
Appearance:	White powder
Purity:	98~102%
Package details:	1kg/foil bag; 25kg/fiber drum
Brand:	Fortunachem

Propafenone Hydrochloride is a prescription medication belonging to a class of drugs called Class 1C antiarrhythmics. It is used to treat certain types of serious, abnormal heart rhythms (arrhythmias), specifically those that occur in the ventricles (the lower chambers of the heart) or the atria (the upper chambers).

Its most common brand name in the United States is Rythmol or Rythmol SR (the sustained-release version).

How Does It Work? (Mechanism of Action)

Propafenone works by stabilizing the heart's rhythm through two primary mechanisms:

Sodium Channel Blockade: As a Class 1C antiarrhythmic, it primarily blocks the sodium channels in heart muscle cells. This action slows the rate at which electrical impulses are conducted through the heart. This helps to prevent the heart from beating too fast and disrupts the chaotic electrical pathways that cause arrhythmias.
Beta-Blockade: Propafenone also has mild to moderate beta-blocking properties. Beta-blockers work by blocking the effect of adrenaline on the heart, which helps to slow the heart rate and reduce the force of contraction. This dual action makes it effective for a range of arrhythmias.

What Is It Used For? (Indications)

Propafenone is prescribed to:

Maintain normal sinus rhythm (a regular heart rhythm) in patients with symptomatic atrial fibrillation (AFib) or atrial flutter.

Treat documented life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia.

Crucial Note: Because it can potentially cause new, serious arrhythmias (a side effect called proarrhythmia), its use is typically reserved for patients without structural heart disease (e.g., no significant heart failure, scarring, or ischemia) and for whom the benefits outweigh the significant risks.

Important Side Effects and Warnings

Propafenone is a powerful drug with several serious risks that require careful monitoring by a cardiologist.

Serious Side Effects (require immediate medical attention):

New or Worsened Arrhythmias (Proarrhythmia): The drug can sometimes cause the very problem it is meant to treat, including life-threatening ventricular tachycardia.
Heart Failure: It can worsen existing heart failure or reduce the heart's pumping strength due to its negative inotropic effect.
Effects on Pacemakers: It can alter the pacing and sensing thresholds of implanted pacemakers and defibrillators (ICDs).
Lupus Erythematosus: Can rarely cause or exacerbate drug-induced lupus.
Blood Disorders: May cause agranulocytosis (a dangerous drop in white blood cells).

Common Side Effects:

Unusual or metallic taste in the mouth (very common)
Dizziness, lightheadedness
Nausea, vomiting, constipation
Blurred vision
Fatigue
Shortness of breath

Key Considerations and Contraindications

Contraindications: It should NOT be used in patients with:

Uncontrolled heart failure
Certain types of pre-existing heart block (without a pacemaker)
Severe bradycardia (very slow heart rate)
Significant hypotension (low blood pressure)
Imbalance of electrolytes (e.g., low potassium or magnesium)
Severe lung disease like asthma (due to its beta-blocking effects)

Drug Interactions: It has numerous dangerous interactions with other drugs, including other antiarrhythmics, beta-blockers, antidepressants (SSRIs), warfarin (increases its levels), and digoxin.
Genetic Metabolism: How a patient metabolizes the drug can vary genetically, affecting the required dose and risk of side effects.

Disclaimer: This information is for educational purposes only. Propafenone is a high-risk medication that must be managed by a cardiologist. Always follow your doctor's instructions and report any side effects immediately.