Nelarabine is used as a pharmaceutical intermediate.
Nelarabine is demethylated from methyl to ara-G under the action of adenosine deaminase (ADA) and then converted to active ara-G triphosphate (ara-GTP) by monophosphorylation pathway under the action of deoxyguanosine kinase and deoxycytidine kinase. ara-GTP can gradually accumulate in leukemia blasts and bind to DNA, thereby inhibiting DNA synthesis and promoting leukemia cell death.
|Appearance||White or white crystalline powder||Conform|
|Loss on drying||≤0.5%||0.06%|
|Residue on Ignition||≤0.1%||0.06%|
|Appearance:||White or off white crystalline powder|
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