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Oxantel Pamoate is an anthelmintic salt used against whipworm (Trichuris trichiura).
Composition:
Salt of oxantel (cholinergic agonist; C₁₁H₁₅N₂O⁺) + pamoic acid (C₂₃H₁₅O₆⁻; ensures gut-localized action).
Mechanism:
Activates nicotinic receptors → paralyzes worms.
Use:
Whipworm-specific: Highly effective where albendazole fails.
Combined with pyrantel pamoate/albendazole for broad-spectrum deworming.
Advantages:
Minimal systemic absorption (<10%); low toxicity.
Single oral dose (15–30 mg/kg).
Status:
WHO-recommended for soil-transmitted helminth programs in endemic areas.
Oxantel Pamoate is a salt complex combining the anthelmintic agent oxantel with pamoic acid (embonic acid). Below is its chemical profile:
Components:
Oxantel: A meta-oxyphenol derivative of pyrantel (C<sub>11</sub>H<sub>14</sub>N<sub>2</sub>O).
Pamoate: Divalent anion from pamoic acid (C<sub>23</sub>H<sub>16</sub>O<sub>6</sub>).
Formula:
(C<sub>11</sub>H<sub>15</sub>N<sub>2</sub>O)<sup>+</sup>·(C<sub>23</sub>H<sub>15</sub>O<sub>6</sub>)<sup>−</sup>
Molecular weight: ~603 g/mol.
Structure:
Oxantel: Contains methyl-pyridyl + hydroxyphenyl groups.
Pamoate: Two naphthol rings linked via methylene bridge.
Anthelmintic: Specifically targets whipworm (Trichuris trichiura).
Action: Depolarizes nematode muscles → paralysis (nicotinic receptor agonist).
Poor absorption: Acts locally in the gut (pamoate ensures slow release).
Combination therapy: Paired with pyrantel pamoate or albendazole for broad-spectrum deworming.
Dose: Typically 15–30 mg/kg (single oral dose).
Low systemic toxicity (GI side effects: nausea, abdominal pain).
Oxantel Pamoate is an anthelmintic salt formed between oxantel (a cholinergic agonist) and pamoic acid. Its structure leverages pamoate’s insolubility to localize action in the intestines. Specifically effective against whipworm infections, it paralyzes worms by activating nicotinic receptors. Used orally in combination therapies (e.g., with pyrantel) for soil-transmitted helminths. Advantages include minimal absorption (<10%) and low systemic toxicity. Common brands include Quantrel Plus®. Molecular weight: ~603 g/mol.
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