Topiramate is a broad-spectrum antiepileptic drug that can be used to control different types of epilepsy; its efficacy and pharmacokinetics are good.
TPM can exert its efficacy in treating epilepsy through various kinds of mechanisms including:
1, blocking the voltage-dependent sodium channels and thereby reducing the duration of epileptic discharges and the number of action potentials generated during each discharge. 2, antagonizing kainate/AMPA--glutamate receptors. 3, enhancing the GABA activity in the non-benzodiazepine position of the GABA receptor. 4, mildly inhibiting carbonic anhydrase. 5, blocking the T-type calcium channels. 6, block the activity of the excitatory neurotransmitter of the central nervous AMPA glutamate receptor.
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