Isotretinoin is the first generation of tretinoin, which has anti-grease effects and has a special effect on severe acne.
The mechanism of action of isotretinoin is as follows: (1) It has the effect of narrowing the sebaceous glands, inhibiting the activity of the sebaceous glands, and reducing the secretion of the sebaceous glands, thereby inhibiting the reproduction of Propionibacterium acnes that grows in a lipid-dependent environment. (2) It has anti-keratinization, inhibits the excessive proliferation of epidermal cells and promotes their differentiation, and can reduce the keratosis of the hair follicle orifice and sebaceous duct. (3) It can also affect the function of monocytes and lymphocytes, inhibit the chemotaxis of neutrophils and have anti-inflammatory activity. (4) Selectively binds to retinoid nucleoreceptors to exert therapeutic effects. Inhibits the proliferation of Corynebacterium acnes, immunostimulant at low doses and immunosuppressive at high doses. (5) It can inhibit the formation of collagenase and gelatinase in the skin, and can inhibit the activity of ornithine decarboxylase. Because the induction of ornithine decarboxylase can play a major role in skin mutations, isotretinoin can also inhibit tumorigenesis. (6) When topically applied, the mechanism of action of this product is similar to that of tretinoin, which can induce epidermal cell proliferation, promote the differentiation of epidermal cell granules into the stratum corneum, and regulate the keratin plugin of the abnormal process of epithelial keratinization of hair follicles, thereby exerting a therapeutic effect.
|Appearance||Yellow crystalline powder||Conform|
|Residue on ignition||≤0.1%||0.05%|
|Loss on drying||≤0.5%||0.2%|
|Assay||98.0% - 102.0%||99.4%|
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|Appearance:||Yellow crystalline powder|
|Purity:||98.0% - 102.0%|
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