Metformin Hydrochloride/HCL 1,1-Dimethylbiguanide hydrochloride is an anti-diabetic agent that reduces blood glucose levels and improves insulin sensitivity.
The main effect of metformin hydrochloride is to reduce the secretion of glucagon in A cells, promote the conversion of glucose into glycogen, and has the property of not stimulating islet β-cells to secrete insulin. The mechanism of action of metformin hydrochloride is as follows: 1. Increase the sensitivity of surrounding tissues to insulin and increase insulin-mediated glucose utilization. 2. Increase the utilization of glucose by non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestines, skin, etc. 3. Inhibit hepatic gluconeogenesis and reduce hepatic glucose output. 4. Inhibit glucose uptake by intestinal wall cells. 5. Inhibit the biosynthesis and storage of cholesterol, reduce blood triglycerides and total cholesterol levels.
|Chromatographic purity||1-cyanoguanidine NMT 0.02%|
Individual impurity NMT 0.1%
Total impurities NMT 0.5%
|Assay||Between 98.5% and 101.0%||99.9%|
|Appearance:||White crystalline powder|
|Purity:||Between 98.5% and 101.0%|
|Package details:||1kg/Foil bag; 25kg/Drum|
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