Tert-Butyl 1-piperazinecarboxylate is an important basic chemical raw material for many antitussives, antiallergic drugs, antipsychotics, antibacterial drugs, and a variety of pesticides.
Tert-Butyl 1-piperazinecarboxylate undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine-containing drug substances, such as trazodone.
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