Hydrochlorothiazide (HCTZ) is a thiazide diuretic with a intermediate-efficacy diuretic effect.
Hydrochlorothiazide has the following effects: (1) sodium excretion diuretic effect: hydrochlorothiazide mainly inhibits the reabsorption of Na+ and Cl- in the anterior and proximal tubules of the distal tubule (lighter effect), so that the excretion of urine sodium, potassium, chloride, phosphorus and magnesium is increased, and the urinary calcium excretion is reduced. (2) Antihypertensive effect: It has a mild and precise antihypertensive effect, and the systolic and diastolic blood pressure in the upright and lying positions can be reduced, and the antihypertensive effect of other antihypertensive drugs can also be increased. (3) Antidiuretic effect: hydrochlorothiazide can reduce the urine output of nephrogenic diabetes insipidus.
|Appearance||White, or practically white, practically odorless, crystalline powder||Conform|
|Loss on drying||≤0.5 %||0.1 %|
|Residue on ignition||≤0.1 %||0.53%|
|Heavy metals||≤ 0.001%||0.31%|
|Any other impurities||≤ 0.5 %||Conforms|
|Total other impurities||≤0.9 %||0.5 %|
|Appearance:||White, or practically white, practically odorless, crystalline powder|
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