Bromodiphenylmethane is used as an intermediate for modafinil. Bromodiphenylmethan is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.
|Apperance||Yellowish brown crystalline powder|
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